C60 fullerene prevents genotoxic effects of doxorubicin in human lymphocytes in vitro

The self-ordering of C60 fullerene, doxorubicin and their mixture precipitated from aqueous solutions was investigated using atomic-force microscopy. The results suggest the complexation between the two compounds. The genotoxicity of doxorubicin in complex with C60 fullerene (C 60+Dox) was evaluated...

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Bibliographic Details
Published in:Ukrainian biochemical journal 2015-01, Vol.87 (1), p.91-98
Main Authors: Afanasieva, K S, Prylutska, S V, Lozovik, A V, Bogutska, K I, Sivolob, A V, Prylutskyy, Yu I, Ritter, U, Scharff, P
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Survival - drug effects
Comet Assay
DNA Fragmentation - drug effects
Doxorubicin - chemistry
Doxorubicin - pharmacology
Drug Carriers - chemistry
Fullerenes - chemistry
Humans
Lymphocytes - cytology
Lymphocytes - drug effects
Microscopy, Atomic Force
Mutagenicity Tests
Primary Cell Culture
Surface Properties
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Summary:The self-ordering of C60 fullerene, doxorubicin and their mixture precipitated from aqueous solutions was investigated using atomic-force microscopy. The results suggest the complexation between the two compounds. The genotoxicity of doxorubicin in complex with C60 fullerene (C 60+Dox) was evaluated in vitro with comet assay using human lymphocytes. The obtained results show that the C60 fullerene prevents the toxic effect of Dox in normal cells and, thus, C60+Dox complex might be proposed for biomedical application.
ISSN:2409-4943