Vitamin D3 seems more appropriate than D2 to sustain adequate levels of 25OHD: a pharmacokinetic approach

The superiority of cholecalciferol (D3) over ergocalciferol (D2) in sustaining serum 25-hydroxy vitamin D (25OHD) levels is controversial. To compare D2 with D3 we performed a single-blind, placebo-controlled randomized trial spanning 11 weeks. Healthy volunteers (n=33, aged 33.4±6 years) were divid...

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Bibliographic Details
Published in:European journal of clinical nutrition 2015-06, Vol.69 (6), p.697-702
Main Authors: Oliveri, B, Mastaglia, S R, Brito, G M, Seijo, M, Keller, G A, Somoza, J, Diez, R A, Di Girolamo, G
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D 2 - blood
Adult
Argentina
Calcifediol - blood
Calciferol
Calcium - blood
Calcium - urine
Cholecalciferol - adverse effects
Cholecalciferol - metabolism
Cholecalciferol - therapeutic use
Dietary supplements
Dietary Supplements - adverse effects
Ergocalciferols - adverse effects
Ergocalciferols - metabolism
Ergocalciferols - therapeutic use
Female
Follow-Up Studies
Half-Life
Health aspects
Hospitals, University
Hospitals, Urban
Humans
Kinetics
Male
Middle Aged
Models, Biological
Nutrition
Personnel, Hospital
Pharmacokinetics
Single-Blind Method
Supplements
Vitamin D
Vitamin D Deficiency - blood
Vitamin D Deficiency - prevention & control
Vitamin D Deficiency - urine
Vitamin D3
Young Adult
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Summary:The superiority of cholecalciferol (D3) over ergocalciferol (D2) in sustaining serum 25-hydroxy vitamin D (25OHD) levels is controversial. To compare D2 with D3 we performed a single-blind, placebo-controlled randomized trial spanning 11 weeks. Healthy volunteers (n=33, aged 33.4±6 years) were divided into three groups (n=11, each): D2, D3 and placebo. Treatment started with a loading dose (100,000 IU) followed by 4800 IU/day (d) between d7 and d20 and follow-up until d77. Serum samples were obtained at baseline and at days 3, 7, 14, 21, 35, 49, 63 and 77. Baseline 25OHD values in the D2 group were lower than those in the D3 and placebo groups (P
ISSN:0954-3007
1476-5640
DOI:10.1038/ejcn.2015.16