Dynamic piezoelectric stimulation enhances osteogenic differentiation of human adipose stem cells

This work reports on the influence of the substrate polarization of electroactive β‐poly(vinylidene fluoride) (β‐PVDF) on human adipose stem cells (hASCs) differentiation under static and dynamic conditions. hASCs were cultured on different β‐PVDF surfaces (non‐poled and “poled −”) adsorbed with fib...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2015-06, Vol.103 (6), p.2172-2175
Main Authors: Ribeiro, Clarisse, Pärssinen, Jenita, Sencadas, Vítor, Correia, Vítor, Miettinen, S., Hytönen, Vesa P., Lanceros-Méndez, Senentxu
Format: Article
Language:English
Subjects:
Adipose Tissue - cytology
Biocompatibility
Biomedical materials
Bones
Cell Differentiation - drug effects
Cells, Cultured
Differentiation
dynamic conditions
Dynamics
Electric Stimulation
electroactive polymer
Human
Humans
osteogenesis
Osteogenesis - drug effects
Polyvinyls - pharmacology
stem cell
Stem cells
Stem Cells - cytology
Tissue engineering
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Summary:This work reports on the influence of the substrate polarization of electroactive β‐poly(vinylidene fluoride) (β‐PVDF) on human adipose stem cells (hASCs) differentiation under static and dynamic conditions. hASCs were cultured on different β‐PVDF surfaces (non‐poled and “poled −”) adsorbed with fibronectin and osteogenic differentiation was determined using a quantitative alkaline phosphatase assay. “Poled −” β‐PVDF samples promote higher osteogenic differentiation, which is even higher under dynamic conditions. It is thus demonstrated that electroactive membranes can provide the necessary electromechanical stimuli for the differentiation of specific cells and therefore will support the design of suitable tissue engineering strategies, such as bone tissue engineering. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 2172–2175, 2015.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.35368