Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes

There is evidence that betatrophin, a hormone derived from adipose tissue and liver, affects the proliferation of pancreatic beta cells in mice. The aim of this study was to examine circulating betatrophin concentrations in Japanese healthy controls and patients with type 1 and type 2 diabetes. A to...

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Bibliographic Details
Published in:Endocrine Journal 2015, Vol.62(5), pp.417-421
Main Authors: Yamada, Hodaka, Saito, Tomoyuki, Aoki, Atsushi, Asano, Tomoko, Yoshida, Masashi, Ikoma, Aki, Kusaka, Ikuyo, Toyoshima, Hideo, Kakei, Masafumi, Ishikawa, San-e
Format: Article
Language:English
Subjects:
Adult
Aged
Angiopoietin-like Proteins
Beta cells proliferation
Betatrophin
Blood Glucose - analysis
C-Peptide - blood
Cholesterol, HDL - blood
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 2 - blood
Fasting
Female
Glycated Hemoglobin A - analysis
Humans
Insulin resistance
Japan
Lipid metabolism
Male
Middle Aged
Peptide Hormones - blood
Triglycerides - blood
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Summary:There is evidence that betatrophin, a hormone derived from adipose tissue and liver, affects the proliferation of pancreatic beta cells in mice. The aim of this study was to examine circulating betatrophin concentrations in Japanese healthy controls and patients with type 1 and type 2 diabetes. A total of 76 subjects (12 healthy controls, 34 type 1 diabetes, 30 type 2 diabetes) were enrolled in the study. Circulating betatrophin was measured with an ELISA kit and clinical parameters related to betatrophin were analyzed statistically. Circulating betatrophin (Log transformed) was significantly increased in patients with diabetes compared with healthy subjects (healthy controls, 2.29 ± 0.51; type 1 diabetes, 2.94 ± 0.44; type 2 diabetes, 3.17 ± 0.18; p
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.EJ14-0525