Ability of Reduced Lung Function to Predict Development of Atrial Fibrillation in Persons Aged 45 to 84 Years (from the Multi-Ethnic Study of Atherosclerosis-Lung Study)

Atrial fibrillation (AF) occurs frequently in patients with chronic obstructive pulmonary disease. Epidemiologic studies have found inconsistent associations between lung function and AF, and none have studied pulmonary emphysema, which overlaps only partially with chronic obstructive pulmonary dise...

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Bibliographic Details
Published in:The American journal of cardiology 2015-06, Vol.115 (12), p.1700-1704
Main Authors: Chahal, Harjit, MD, MPH, Heckbert, Susan R., MD, PhD, Barr, R. Graham, MD, DrPH, Bluemke, David A., MD, PhD, Jain, Aditya, MD, MPH, Habibi, Mohammadali, MD, Alonso, Alvaro, MD, PhD, Kronmal, Richard, PhD, Jacobs, David R., PhD, Lima, Joao A.C., MD, Watson, Karol E., MD, PhD, Liu, Kiang, PhD, Smith, Lewis J., MD, Greenland, Philip, MD
Format: Article
Language:English
Subjects:
African Americans
Age
Aged
Aged, 80 and over
Atherosclerosis
Atrial Fibrillation - ethnology
Atrial Fibrillation - physiopathology
Cardiovascular
Cardiovascular disease
Cholesterol
Chronic obstructive pulmonary disease
Classification
Confidence intervals
Diabetes
Ethnicity
Female
Glucose
Health risk assessment
Heart rate
Hispanic people
Hospitals
Humans
Hypertension
Lipoproteins
Male
Medicare
Middle Aged
Older people
Predictive Value of Tests
Pulmonary Emphysema - ethnology
Pulmonary Emphysema - physiopathology
Respiratory Function Tests
Risk factors
Severity of Illness Index
Smoking
Studies
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Summary:Atrial fibrillation (AF) occurs frequently in patients with chronic obstructive pulmonary disease. Epidemiologic studies have found inconsistent associations between lung function and AF, and none have studied pulmonary emphysema, which overlaps only partially with chronic obstructive pulmonary disease in the general population. The aim of this study was to assess the relation among lung function measured by spirometry, the percentage of emphysema-like lung on computed tomography, and incident AF. The Multi-Ethnic Study of Atherosclerosis (MESA) is a multicenter cohort study following 6,814 subjects free of clinical cardiovascular disease, including AF, at baseline. Spirometry was performed in a subset of 3,965 participants. Percentage emphysema was defined on baseline computed tomographic scans as lung regions
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2015.03.018