Efficacy of topical tacrolimus for oral lichen planus: real-life experience in a retrospective cohort of patients with a review of the literature

Background and Objective Management of oral lichen planus (OLP) is challenging and therapeutic options are limited. The use of topical tacrolimus has shown promising results. We reviewed our daily life experience with topical tacrolimus in OLP patients. Methods This retrospective unicentre study inc...

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Bibliographic Details
Published in:Journal of the European Academy of Dermatology and Venereology 2015-06, Vol.29 (6), p.1107-1113
Main Authors: Ribero, S., Stieger, M., Quaglino, P., Hongang, T., Bornstein, M.M., Naldi, L., Borradori, L.
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Aged
Aged, 80 and over
Female
Humans
Immunosuppressive Agents - administration & dosage
Lichen Planus, Oral - complications
Lichen Planus, Oral - drug therapy
Male
Middle Aged
Pain - etiology
Pain Measurement
Retrospective Studies
Tacrolimus - administration & dosage
Treatment Outcome
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Summary:Background and Objective Management of oral lichen planus (OLP) is challenging and therapeutic options are limited. The use of topical tacrolimus has shown promising results. We reviewed our daily life experience with topical tacrolimus in OLP patients. Methods This retrospective unicentre study included all 21 patients with OLP, which were evaluated over a 53‐month period and treated with topical tacrolimus. Patients were initially given a topical preparation of 0.1% tacrolimus twice daily. The response to treatment was assessed using a 4‐point scale at month 2 and 6: complete response of affected area (CR), major remission (>50%, MR), partial remission (25–50%, PR) and either no response (
ISSN:0926-9959
1468-3083
DOI:10.1111/jdv.12758