SYMPLICITY HTN-Japan　– First Randomized Controlled Trial of Catheter-Based Renal Denervation in Asian Patients

Background:SYMPLICITY HTN-Japan is a prospective, randomized, controlled trial comparing renal artery denervation (RDN) with standard pharmacotherapy for treatment of resistant hypertension (systolic blood pressure [SBP] ≥160 mmHg on ≥3 anti-hypertensive drugs including a diuretic for ≥6 weeks). Whe...

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Bibliographic Details
Published in:Circulation Journal 2015/05/25, Vol.79(6), pp.1222-1229
Main Authors: Kario, Kazuomi, Ogawa, Hisao, Okumura, Ken, Okura, Takafumi, Saito, Shigeru, Ueno, Takafumi, Haskin, Russel, Negoita, Manuela, Shimada, Kazuyuki, on behalf of the SYMPLICITY HTN-Japan Investigators
Format: Article
Language:English
Subjects:
Aged
Ambulatory blood pressure
Antihypertensive Agents - therapeutic use
Asia
Asian Continental Ancestry Group
Blood Pressure Monitoring, Ambulatory
Catheter Ablation
Combined Modality Therapy
Comorbidity
Female
Humans
Hypertension - drug therapy
Hypertension - surgery
Japan
Male
Middle Aged
Mineralocorticoid Receptor Antagonists - therapeutic use
Prospective Studies
Renal Artery - innervation
Renal denervation
Research Design
Resistant hypertension
Sample Size
Sympathectomy - methods
Treatment Outcome
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Summary:Background:SYMPLICITY HTN-Japan is a prospective, randomized, controlled trial comparing renal artery denervation (RDN) with standard pharmacotherapy for treatment of resistant hypertension (systolic blood pressure [SBP] ≥160 mmHg on ≥3 anti-hypertensive drugs including a diuretic for ≥6 weeks). When SYMPLICITY HTN-3 failed to meet the primary efficacy endpoint, the HTN-Japan enrollment was discontinued before completion.Methods and Results:The 6-month change in office and 24-h ambulatory SBP were compared between RDN (n=22) and control (n=19) subjects. Mean baseline office SBP was 181.0±18.0 mmHg and 178.7±17.8 mmHg for the RDN and control groups, respectively. The 6-month office SBP change was –16.6±18.5 mmHg for RDN subjects (P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-15-0150