Interventionalist Perspective on the New Endovascular Trials

Three recently published trials have conclusively proven the benefit of mechanical endovascular thrombectomy over best medical therapy for patients with acute ischemic stroke and large vessel occlusion. These trials shared some features and differed in others. These similarities and differences in t...

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Bibliographic Details
Published in:Stroke (1970) 2015-06, Vol.46 (6), p.1440-1446
Main Authors: Pierot, Laurent, Derdeyn, Colin
Format: Article
Language:English
Subjects:
Brain Ischemia - surgery
Clinical Trials as Topic - methods
Clinical Trials as Topic - standards
Endovascular Procedures - instrumentation
Endovascular Procedures - methods
Humans
Stroke - surgery
Thrombectomy - instrumentation
Thrombectomy - methods
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Summary:Three recently published trials have conclusively proven the benefit of mechanical endovascular thrombectomy over best medical therapy for patients with acute ischemic stroke and large vessel occlusion. These trials shared some features and differed in others. These similarities and differences in trial design and execution affect the conclusions and recommendations that can be made from the data. We will examine the implications of these studies for neurointerventionists, both for current practice and for future studies. In particular, we will focus on procedural details such as patient selection, devices, adjunctive therapies, treatment time windows, and performance metrics.
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.115.008416