Effect of Recent Spinal Cord Injury on Wnt Signaling Antagonists (Sclerostin and Dkk‐1) and Their Relationship With Bone Loss. A 12‐Month Prospective Study

Spinal cord injury (SCI) has been associated with a marked increase in bone loss and bone remodeling, especially short‐term after injury. The absence of mechanical load, mediated by osteocyte mechanosensory function, seems to be a causative factor related to bone loss in this condition. However, the...

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Bibliographic Details
Published in:Journal of bone and mineral research 2015-06, Vol.30 (6), p.1014-1021
Main Authors: Gifre, Laia, Vidal, Joan, Carrasco, Josep L, Filella, Xavier, Ruiz‐Gaspà, Silvia, Muxi, Africa, Portell, Enric, Monegal, Ana, Guañabens, Nuria, Peris, Pilar
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biomarkers - blood
Bone Morphogenetic Proteins - blood
Bone Resorption - blood
Bone Resorption - etiology
DKK‐1
Female
Follow-Up Studies
Genetic Markers
Humans
Intercellular Signaling Peptides and Proteins - blood
Male
Middle Aged
OSTEOPOROSIS
Prospective Studies
SCLEROSTIN
Spinal Cord Injuries - blood
Spinal Cord Injuries - complications
SPINAL CORD INJURY
WNT SIGNALING
Wnt Signaling Pathway
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Summary:Spinal cord injury (SCI) has been associated with a marked increase in bone loss and bone remodeling, especially short‐term after injury. The absence of mechanical load, mediated by osteocyte mechanosensory function, seems to be a causative factor related to bone loss in this condition. However, the pathogenesis and clinical management of this process remain unclear. Therefore, the aim of the study was to analyze the effect of recent SCI on the Wnt pathway antagonists, sclerostin and Dickkopf (Dkk‐1), and their relationship with bone turnover and bone mineral density (BMD) evolution. Forty‐two patients (aged 35 ± 14yrs) with a recent (
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.2423