Early diagnosis of cardiac involvement in idiopathic inflammatory myopathy by cardiac magnetic resonance tomography

The aim of this study was to investigate cardiac involvement in patients with idiopathic inflammatory myopathies excluding inclusion body myositis with cardiac magnetic resonance tomography (CMR). A case series of 53 patients with polymyositis, dermatomyositis, or non-specific myositis underwent CMR...

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Bibliographic Details
Published in:Journal of neurology 2015-04, Vol.262 (4), p.949-956
Main Authors: Rosenbohm, Angela, Buckert, Dominik, Gerischer, Nora, Walcher, Thomas, Kassubek, Jan, Rottbauer, Wolfgang, Ludolph, Albert C., Bernhardt, Peter
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - metabolism
Biopsy
Cloning
Creatine Kinase - blood
Disease
Early Diagnosis
Electron Transport Complex IV - metabolism
Female
Gadolinium - metabolism
Heart failure
Humans
Laboratories
Male
Medicine
Medicine & Public Health
Monoclonal antibodies
Muscle, Skeletal - metabolism
Muscle, Skeletal - pathology
Musculoskeletal system
Myocarditis
Myocardium - pathology
Myositis - blood
Myositis - diagnosis
Natriuretic Peptide, Brain - metabolism
Neurology
Neuroradiology
Neurosciences
Original Communication
Patients
Risk Factors
Statistics, Nonparametric
Succinate Dehydrogenase - metabolism
Tomography
Tomography, X-Ray Computed
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Summary:The aim of this study was to investigate cardiac involvement in patients with idiopathic inflammatory myopathies excluding inclusion body myositis with cardiac magnetic resonance tomography (CMR). A case series of 53 patients with polymyositis, dermatomyositis, or non-specific myositis underwent CMR including functional imaging, T1-weighted, and late gadolinium enhancement (LGE) imaging. T1-weighted and LGE images were analyzed for myocardial enhancement. Reduced left ventricular function (LVF) was found in 9 (7 %) patients. Patients with reduced LVF more often presented with early and late myocardial enhancement ( p  = 0.014 and p  = 0.001). In 33 (62.3 %) patients, LGE was observed by CMR. These patients had significantly lower left ventricular ejection fractions ( p  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-014-7623-1