Supramolecular hydrogels as drug delivery systems

Drug delivery from a hydrogel carrier implanted under the kidney capsule is an innovative way to induce kidney tissue regeneration and/or prevent kidney inflammation or fibrosis. We report here on the development of supramolecular hydrogels for this application. Chain-extended hydrogelators containi...

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Bibliographic Details
Published in:International journal of biological macromolecules 2015-04, Vol.75, p.426-436
Main Authors: Saboktakin, Mohammad reza, Tabatabaei, Roya Mahdavi
Format: Article
Language:English
Subjects:
Biomedical Technology
Drug delivery
Drug Delivery Systems
Hydrogels - chemistry
Macromolecular Substances - chemistry
Nanocomposites - chemistry
Physical properties
Supramolecular hydrogels
Temperature
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Summary:Drug delivery from a hydrogel carrier implanted under the kidney capsule is an innovative way to induce kidney tissue regeneration and/or prevent kidney inflammation or fibrosis. We report here on the development of supramolecular hydrogels for this application. Chain-extended hydrogelators containing hydrogen bonding units in the main chain, and bifunctional hydrogelators end-functionalized with hydrogen bonding moieties, were made. The influence of these hydrogels on the renal cortex when implanted under the kidney capsule was studied. The overall tissue response to these hydrogels was found to be mild, and minimal damage to the cortex was observed, using the infiltration of macrophages, formation of myofibroblasts, and the deposition of collagen III as relevant read-out parameters. Differences in tissue response to these hydrogels could be related to the different physico-chemical properties of the three hydrogels.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2015.02.006