Reproducible Matrix Deposition for MALDI MSI Based on Open-Source Software and Hardware

The new open-source software and hardware matrix deposition device named iMatrixSpray was optimized and specified for homogeneity, reproducibility, and sensitivity in MS imaging experiments. The results confirm the design claims, with the device delivering uniform coatings with a constant quality fr...

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Bibliographic Details
Published in:Journal of the American Society for Mass Spectrometry 2015-06, Vol.26 (6), p.911-914
Main Authors: Stoeckli, Markus, Staab, Dieter
Format: Article
Language:English
Subjects:
Analytical Chemistry
Animals
Bioinformatics
Biotechnology
Chemistry
Chemistry and Materials Science
Deposition
Equipment Design
Focus: Imaging Mass Spectrometry: Research Article
Freeware
Hardware
Information Dissemination
Mass spectrometry
Open source software
Organic Chemistry
Pharmacokinetics
Proteomics
Rats
Reproducibility
Reproducibility of Results
Software
Specimen Handling
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - instrumentation
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
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Description
Summary:The new open-source software and hardware matrix deposition device named iMatrixSpray was optimized and specified for homogeneity, reproducibility, and sensitivity in MS imaging experiments. The results confirm the design claims, with the device delivering uniform coatings with a constant quality from experiment to experiment. The robustness in combination with the open design allows developing and sharing of matrix deposition and sample preparation protocols between labs. This tool therefore enables researchers to enter the field of MALDI MSI without previous experience in matrix coating. Graphical Abstract ᅟ
ISSN:1044-0305
1879-1123
DOI:10.1007/s13361-015-1099-9