Genistein Exerts Neuroprotective Effect on Focal Cerebral Ischemia Injury in Rats

Brain ischemia and treatment are one of the important topics in neurological science. Free oxygen radicals and inflammation formed after ischemia are accepted as the most important causes of damage. Currently, there are studies on many chemopreventive agents to prevent cerebral ischemia damage. Our...

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Bibliographic Details
Published in:Inflammation 2015-06, Vol.38 (3), p.1311-1321
Main Authors: Aras, Adem Bozkurt, Guven, Mustafa, Akman, Tarik, Alacam, Hasan, Kalkan, Yildiray, Silan, Coskun, Cosar, Murat
Format: Article
Language:English
Subjects:
Animals
Apoptosis - drug effects
Biomedical and Life Sciences
Biomedicine
Brain Ischemia - drug therapy
Caspase 3 - metabolism
Caspase 9 - metabolism
Cysteine Proteases - metabolism
Genistein - therapeutic use
Immunology
Inflammation - drug therapy
Internal Medicine
Male
Malondialdehyde - metabolism
Neuroprotective Agents - therapeutic use
Nuclear Respiratory Factor 1 - metabolism
Oxidative Stress - drug effects
Pathology
Pharmacology/Toxicology
Random Allocation
Rats
Rats, Sprague-Dawley
Rheumatology
Stroke - drug therapy
Superoxide Dismutase - metabolism
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Summary:Brain ischemia and treatment are one of the important topics in neurological science. Free oxygen radicals and inflammation formed after ischemia are accepted as the most important causes of damage. Currently, there are studies on many chemopreventive agents to prevent cerebral ischemia damage. Our aim is to research the preventive effect of the active ingredient in genistein, previously unstudied, on oxidative damage in cerebral ischemia. Rats were randomly divided into three groups: control group (no medication or surgical procedure), ischemia group, and artery ischemia + genistein group, sacrificed at 24 h after ischemia. The harvested brain tissue from the right hemisphere was investigated histopathologically and for tissue biochemistry. Superoxide dismutase and nuclear respiratory factor 1 values decreased after ischemia and they increased after genistein treatment, while increased malondialdehyde levels after ischemia reduced after treatment. Apoptosis-related cysteine peptidase caspase-3 and caspase-9 values increased after ischemia, but reduced after treatment. Our study revealed that genistein treatment in cerebral ischemia reduced oxidative stress and neuronal degeneration. We believe that genistein treatment may be an alternative treatment method.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-014-0102-0