The Preventive Misconception: Experiences from CAPRISA 004

Overestimating personal protection afforded by participation in a preventive trial, e.g. harboring a “preventive misconception” (PM), raises theoretical ethical concerns about the adequacy of the informed consent process, behavioral disinhibition, and adherence to prevention interventions. Data from...

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Bibliographic Details
Published in:AIDS and behavior 2014-09, Vol.18 (9), p.1746-1752
Main Authors: Dellar, Rachael C., Abdool Karim, Quarraisha, Mansoor, Leila E., Grobler, Anneke, Humphries, Hilton, Werner, Lise, Ntombela, Fanelesibonge, Luthuli, Londiwe, Abdool Karim, Salim S.
Format: Article
Language:English
Subjects:
Acquired Immune Deficiency Syndrome
Adenine - administration & dosage
Adenine - analogs & derivatives
Adolescent
Adult
Anti-HIV Agents - administration & dosage
Anti-Infective Agents, Local
Antimicrobial agents
Clinical trials
Condoms
Evidence Based Practice
Female
Gels
Health Psychology
HIV
HIV Infections - prevention & control
Human immunodeficiency virus
Humans
Infectious Diseases
Informed Consent
Intervention
Medication Adherence
Medicine
Medicine & Public Health
Motivation
Organophosphonates - administration & dosage
Original Paper
Participation
Perceptions
Personal Satisfaction
Prevention
Preventive medicine
Protection
Public Health
South Africa
Symptoms
Tenofovir
Trials
Young Adult
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Summary:Overestimating personal protection afforded by participation in a preventive trial, e.g. harboring a “preventive misconception” (PM), raises theoretical ethical concerns about the adequacy of the informed consent process, behavioral disinhibition, and adherence to prevention interventions. Data from the CAPRISA 004 1 % tenofovir gel trial were utilized to empirically evaluate these concerns. We found it necessary to re-think the current definition of PM during evaluation to distinguish between true misconception and reasonable inferences of protection based on increased access to evidence-based prevention interventions and/or clinical care. There was a significant association between PM and decreased condom use ( p  
ISSN:1090-7165
1573-3254
DOI:10.1007/s10461-014-0771-6