Effects of PEGylated porcine glucagon-like peptide-2 therapy in weaning piglets challenged with lipopolysaccharide

•A pig model of gut injury was established by injecting Escherichia coli LPS.•PEGylated pGLP-2 infusion ameliorated intestinal injury by increasing the villus height/crypt depth ratio and decreasing the pro-inflammatory cytokines levels.•The therapeutic effects of PEG–pGLP-2 may be associated with r...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2014-08, Vol.58, p.7-13
Main Authors: Qi, Ke-ke, Wu, Jie, Xu, Zi-wei
Format: Article
Language:English
Subjects:
Animals
Caspase-3
Crypts
Cytokines
Gene expression
Glucagon-Like Peptide 2 - pharmacology
Inflammatory cytokines
Infusion
Injury prevention
Interferon-gamma - metabolism
Interleukin-8 - metabolism
Jejunum - metabolism
Jejunum - pathology
Lipopolysaccharides - toxicity
PEGylated
Piglet
Polyethylene Glycols - pharmacology
Porcine glucagon-like peptide-2
Saline solutions
Secretions
Swine
Therapy
Tight junction protein
Tumor Necrosis Factor-alpha - metabolism
Weaning
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Summary:•A pig model of gut injury was established by injecting Escherichia coli LPS.•PEGylated pGLP-2 infusion ameliorated intestinal injury by increasing the villus height/crypt depth ratio and decreasing the pro-inflammatory cytokines levels.•The therapeutic effects of PEG–pGLP-2 may be associated with reduced cell apoptosis. This study aims to evaluate the therapeutic effect of polyethylene glycosylated porcine glucagon-like peptide-2 (pGLP-2), a long-acting form of pGLP-2, in lipopolysaccharide (LPS)-challenged piglets. Eighteen 21-day-old weaning piglets were randomly assigned into three groups: control (saline solution), LPS (100μg/kg LPS), and PEG–pGLP-2 (10nmol/kg PEG–pGLP-2+100μg/kg LPS). All treatments were administered intraperitoneally. Compared with the control treatment, LPS treatment significantly decreased (P0.05). Specifically, PEG–pGLP-2 infusion significantly increased the villus height/crypt depth ratio of the duodenum (P
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2014.05.007