Complex micelles with the bioactive function of reversible oxygen transfer

A complex micelle as a hemoglobin functional model with the biaoactive function of reversible oxygen transfer has been constructed through the hierarchical assembly of the diblock copolymer poly（ethylene glycol）-block- poly（4-vinylpyridine-co-N-heptyl-4-vinylpyridine） （PEG-b-P（4VP-co-4VPHep））, tetra...

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Bibliographic Details
Published in:Nano research 2015-02, Vol.8 (2), p.491-501
Main Authors: Shen, Liangliang, Zhao, Lizhi, Qu, Rui, Huang, Fan, Gao, Hongjun, An, Yingli, Shi, Linqi
Format: Article
Language:English
Subjects:
4-乙烯基吡啶
Aqueous solutions
Atomic/Molecular Structure and Spectra
Biomedicine
Biotechnology
Chemical synthesis
Chemistry and Materials Science
Condensed Matter Physics
Construction
Cyclodextrins
Hemoglobin
Holes
Hypoxia
Laboratories
Materials Science
Mathematical models
Medical services
Micelles
Nanostructure
Nanotechnology
Oxygen transfer
Physiology
Polypeptides
Pyridines
Research Article
主客体相互作用
二嵌段共聚物
可逆性
复合物
氧转移
生物活性
胶束结构
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Summary:A complex micelle as a hemoglobin functional model with the biaoactive function of reversible oxygen transfer has been constructed through the hierarchical assembly of the diblock copolymer poly（ethylene glycol）-block- poly（4-vinylpyridine-co-N-heptyl-4-vinylpyridine） （PEG-b-P（4VP-co-4VPHep））, tetrakis（4-sulfonatophenyl）porphinato iron（II） （Fe（II）TPPS） and β-cyclodextrin （β-CD）. The μ-oxo dimer of Fe（II）TPPS was successfully inhibited because the Fe（II）TPPS was included into the cavities of β-CDs through host-guest interaction. Fe（II）TPPS coordinated with pyridine groups functions as the active site to reversibly bind dioxygen. In adition, the host-guest inclusion （β-CD/Fe（II）TPPS） was encapsulated in the hydrophobic core of the complex micelle and tightly fixed by P4VP chains. The hydrophilic PEG blocks stretched in aqueous solution to constitute the shells which stabilize the structure of the complex micelle as well as endow the complex micelle with sufficient blood circulation time. Dioxygen can be bound to the Fe（II）TPPS located in the confined space and excellent reversibility of the binding-release process of dioxygen can be achieved. The quaternary amine N-heptyl-4-vinylpyridine can coerce abundant S2O4^2- ions into the core of the complex micelle to facilitate the self-reduction process. Dioxygen adducts （Fe（II）TPPS（O2）） were effectively protected by the double hydrophobic barriers constructed by the cavity of the cyclodextrin and the core of the complex micelle which enhances the ability to resist nucleophilic molecules. Therefore, the rationally designed amphiphilic structure can work as a promising artificial O2 carrier. Potentially, the complex micelle can be expected to improve the treatment of diseases linked with hypoxia.
ISSN:1998-0124
1998-0000
DOI:10.1007/s12274-014-0651-4