The timing of administration of antenatal corticosteroids in women with indicated preterm birth

Objective We sought to determine the timing of administration of antenatal corticosteroids (AS) for indicated preterm births and to identify which indications are associated with the most optimal timing of administration. Study Design This was a retrospective cohort of patients who received AS in an...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2015-05, Vol.212 (5), p.645.e1-645.e4
Main Authors: Adams, Tracy M., DO, Kinzler, Wendy L., MD, Chavez, Martin R., MD, Vintzileos, Anthony M., MD
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - administration & dosage
Adult
antenatal corticosteroids
Cohort Studies
decision to administer antenatal corticosteroids
Delivery, Obstetric - methods
Drug Administration Schedule
Female
Humans
indicated preterm birth
Obstetrics and Gynecology
Perinatal Care - methods
Pregnancy
Premature Birth
preterm birth
Retrospective Studies
Time Factors
timing of antenatal corticosteroids
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Summary:Objective We sought to determine the timing of administration of antenatal corticosteroids (AS) for indicated preterm births and to identify which indications are associated with the most optimal timing of administration. Study Design This was a retrospective cohort of patients who received AS in anticipation of indicated preterm birth from 2009 through 2012 at Winthrop University Hospital, Mineola, NY. Medical records of patients who received AS, as identified through the hospital pharmacy database, were reviewed. Patients were included if they had a singleton or twin gestation and they received AS for maternal or fetal indications. Women were excluded if they received AS for spontaneous preterm labor or preterm rupture of membranes. Maternal demographic and obstetrical characteristics were compared between those who received AS ≤7 days vs >7 days from delivery using parametric and nonparametric tests with relative risks and 95% confidence intervals. P
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2014.11.021