The coronary artery disease-associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPARγ

The coronary artery disease-associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPARγ

•C6ORF105 is expressed in human macrophages in vitro.•C6ORF105 is expressed in macrophages resident in human atherosclerotic lesions.•In human atherosclerotic lesions, C6ORF105 positively correlates with PPARγ.•Expression of C6ORF105 is induced by PPARγ activation in human macrophages. Coronary arte...

Full description

Saved in:
Bibliographic Details
Published in:FEBS letters 2015-02, Vol.589 (4), p.461-466
Main Authors: Chinetti-Gbaguidi, G., Copin, C., Derudas, B., Vanhoutte, J., Zawadzki, C., Jude, B., Haulon, S., Pattou, F., Marx, N., Staels, B.
Format: Article
Language:eng
Subjects:
Atherosclerosis
Atherosclerosis - metabolism
Cells, Cultured
Coronary Artery Disease - genetics
Diabetes Mellitus, Type 2 - metabolism
Female
Gene Expression
Gene regulation
Humans
Macrophage
Macrophages - metabolism
Membrane Proteins - biosynthesis
Membrane Proteins - genetics
Obesity - metabolism
PPAR gamma - physiology
Transcription factor
Transcriptional Activation
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•C6ORF105 is expressed in human macrophages in vitro.•C6ORF105 is expressed in macrophages resident in human atherosclerotic lesions.•In human atherosclerotic lesions, C6ORF105 positively correlates with PPARγ.•Expression of C6ORF105 is induced by PPARγ activation in human macrophages. Coronary artery disease (CAD) is a major cause of morbidity and mortality. Mutations in C6ORF105, associated with decreased gene expression, positively correlate with the risk of CAD in Chinese populations. Moreover, the C6ORF105-encoded protein may play a role in coagulation. Here, we report that C6ORF105 gene expression is lower in circulating mononuclear cells from obese diabetic than lean subjects. Moreover, C6ORF105 is expressed in human macrophages and atherosclerotic lesions, where its expression positively correlates with expression of the transcription factor Peroxisome Proliferator-Activated Receptor (PPAR)γ. Activation of PPARγ increases, in a PPARγ-dependent manner, the expression of C6ORF105 in human macrophages and atherosclerotic lesions.
ISSN:0014-5793
1873-3468