Platycodin D, a triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice

► PD is a triterpenoid saponin, isolated from the root of Platycodon grandiflorum. ► We aimed to evaluate protective effect of PD on cisplatin-induced nephrotoxicity. ► The levels of oxidant and antioxidant enzymes were examined with histopathological studies. ► PD ameliorated the cisplatin induced...

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Bibliographic Details
Published in:Food and chemical toxicology 2012-12, Vol.50 (12), p.4254-4259
Main Authors: Kim, Tae-Won, Song, In-Bae, Lee, Hong-Ki, Lim, Jong-Hwan, Cho, Eun-Sang, Son, Hwa-Young, Park, Sang-Jin, Kim, Jong-Woo, Yun, Hyo-In
Format: Article
Language:English
Subjects:
Animals
antioxidants
apoptosis
Apoptosis - drug effects
Biological and medical sciences
blood
Blood Urea Nitrogen
Campanulaceae
Cisplatin
Cisplatin - toxicity
creatinine
Creatinine - blood
glutathione
Glutathione - metabolism
glutathione peroxidase
Glutathione Peroxidase - metabolism
histopathology
Kidney - drug effects
Kidney - metabolism
Kidney - pathology
Kidney Diseases - drug therapy
Kidney Diseases - pathology
lipid peroxidation
Lipid Peroxidation - drug effects
Male
Medical sciences
Mice
Mice, Inbred ICR
Nephrotoxicity
NF-kappa B
nitric oxide
Nitric Oxide - blood
Oxidative Stress - drug effects
Plant Roots - chemistry
Platycodin D
Platycodon - chemistry
Platycodon grandiflorum
protective effect
Saponins - pharmacology
superoxide dismutase
Superoxide Dismutase - metabolism
Toxicology
transcription factor NF-kappa B
Triterpenes - pharmacology
urea nitrogen
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Summary:► PD is a triterpenoid saponin, isolated from the root of Platycodon grandiflorum. ► We aimed to evaluate protective effect of PD on cisplatin-induced nephrotoxicity. ► The levels of oxidant and antioxidant enzymes were examined with histopathological studies. ► PD ameliorated the cisplatin induced renal injury by the reduced oxidative stress and apoptosis. Platycodin D (PD) is well known as a potent triterpenoid saponin having various pharmacological activities isolated from the root of Platycodon grandiflorum (Jacq.) A. DC. (Campanulaceae). We aimed to evaluate protective effect of PD on cisplatin (CDDP)-induced nephrotoxicity. Male ICR mice were allocated into five groups as follows: Negative control, CDDP alone and CDDP with PD (0.1, 1 and 5mg/kg) treated group. PD was given for three consecutive days before CDDP injection. Increased blood urea nitrogen (BUN) and creatinine (CRE) levels in CDDP alone treated mice were decreased to normal range by pretreatment with PD. It also decreased nitric oxide (NO) and lipid peroxidation with increased antioxidant enzymes such as glutathione (GSH), glutathione peroxidase (GPx) and superoxide dismutase (SOD) in PD pretreated mice. In histopathological examination, pretreatment with PD showed ameliorated renal injury such as intraluminal cast formation and epithelial desquamation. Furthermore, over-expression of nuclear factor-kappa B p65 and apoptotic cells were suppressed by PD pretreatment. Taken together, PD pretreatment might be beneficial to CDDP-induced nephrotoxicity.
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2012.05.022