Oral nickel exposure may induce Type I hypersensitivity reaction in nickel-sensitized subjects

Little is known about the clinical and immunological changes in the nickel allergic patients with systemic symptoms. We aimed to evaluate T helper cell responses of patients with different clinical presentations due to nickel. Patients having various allergic symptoms and positive patch test results...

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Bibliographic Details
Published in:International immunopharmacology 2015-05, Vol.26 (1), p.92-96
Main Authors: Büyüköztürk, Suna, Gelincik, Aslı, Ünal, Derya, Demirtürk, Mustafa, Çelik, Dolay Damla, Erden, Sacide, Çolakoğlu, Bahattin, Erdem Kuruca, Serap
Format: Article
Language:English
Subjects:
Case-Control Studies
Cell Proliferation - drug effects
Cells, Cultured
Cytokines - immunology
Dental Alloys
Female
Humans
Hypersensitivity, Immediate - chemically induced
Hypersensitivity, Immediate - immunology
Intradermal Tests
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - immunology
Lymphocyte Activation - drug effects
Lymphocyte Activation - immunology
Lymphocyte transformation test
Lymphocytes - drug effects
Lymphocytes - immunology
Male
Middle Aged
Nickel - immunology
Nickel allergy
Patch Tests
Skin - immunology
Systemic nickel allergy
Type I reaction
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Summary:Little is known about the clinical and immunological changes in the nickel allergic patients with systemic symptoms. We aimed to evaluate T helper cell responses of patients with different clinical presentations due to nickel. Patients having various allergic symptoms and positive patch test results to nickel and 20 controls underwent skin prick tests with nickel. IL-10, IL-4, IL-5 and IFN-gamma were measured in the culture supernatants of PBMC stimulated by nickel during lymphocyte proliferation test (LTT). 69 patients (56 female, mean age: 49.2±13.1), 97% having nickel containing dental devices and 20 controls (8 female, mean age 34.9±12.06) were evaluated. Skin prick tests with nickel were positive in 70% of the patients (p
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2015.03.012