Changes in thyroid function with age: results from the Pizarra population-based longitudinal study

Summary Background Results of studies examining the influence of age on thyroid function and TSH levels, in the absence of thyroid disease, remain controversial. The aim of this study was to determine the course of thyroid function over 11 years in a population with normal thyroid function. Methods...

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Bibliographic Details
Published in:International journal of clinical practice (Esher) 2015-05, Vol.69 (5), p.577-587
Main Authors: Lago-Sampedro, A. M, Gutiérrez-Repiso, C., Valdés, S., Maldonado, C., Colomo, N., Almaraz, M. C., Rubio-Martín, E., Morcillo, S., Esteva, I., Ruiz de Adana, M. S., Perez-Valero, V., Soriguer, F., Rojo-Martínez, G., García-Fuentes, E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Aging
Female
Health risk assessment
Humans
Longitudinal Studies
Male
Middle Aged
Population
Prospective Studies
Spain
Thyroid diseases
Thyroid Function Tests
Thyroid Gland - physiology
Thyrotropin - blood
Young Adult
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Summary:Summary Background Results of studies examining the influence of age on thyroid function and TSH levels, in the absence of thyroid disease, remain controversial. The aim of this study was to determine the course of thyroid function over 11 years in a population with normal thyroid function. Methods This is a population‐based prospective study started in 1995–1997 (first phase), and reassessed 6 (second phase) and 11 years later (third phase). Results The TSH and FT4 in the third phase were significantly increased (p = 0.001 and p = 0.001, respectively), with the values being higher particularly from the age of 50 years. In those persons with a baseline TSH ≥ 1.2 and
ISSN:1368-5031
1742-1241
DOI:10.1111/ijcp.12545