Bioactive Metabolites from the Fruits of Psoralea corylifolia

Twenty-four metabolites, including seven new compounds (1–7), were isolated from the dried fruits of Psoralea corylifolia. On the basis of combined spectroscopic and chemical analysis, the new compounds were determined to be six flavonoids (1–6) and a meroterpenoid (7). The absolute configurations o...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2015-04, Vol.78 (4), p.666-673
Main Authors: Won, Tae Hyung, Song, Inn-Hye, Kim, Kuk-Hwa, Yang, Woo-Young, Lee, Sang Kook, Oh, Dong-Chan, Oh, Won-Keun, Oh, Ki-Bong, Shin, Jongheon
Format: Article
Language:English
Subjects:
Aminoacyltransferases - drug effects
Bacterial Proteins - drug effects
Cysteine Endopeptidases - drug effects
Flavonoids - chemistry
Flavonoids - isolation & purification
Fruit - chemistry
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Psoralea - chemistry
Republic of Korea
Staphylococcus - drug effects
Terpenes - chemistry
Terpenes - isolation & purification
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Summary:Twenty-four metabolites, including seven new compounds (1–7), were isolated from the dried fruits of Psoralea corylifolia. On the basis of combined spectroscopic and chemical analysis, the new compounds were determined to be six flavonoids (1–6) and a meroterpenoid (7). The absolute configurations of the natural products obtained, including the previously undetermined 16 and 17, were assigned by several methods, such as NOE spectroscopy, optical rotation, and CD spectroscopy. Several of these compounds exhibited moderate inhibitory activity toward Staphylococcus mutans-derived SrtA (2, 6, and 16) and significant stimulation of SIRT1 activity (2, 3, and 15).
ISSN:0163-3864
1520-6025
DOI:10.1021/np500834d