Treatment patterns of elderly breast cancer patients at two Canadian cancer centres

Abstract Background Treatment of breast cancer in elderly women is limited by declining functional status and life expectancy. The impact of providing less aggressive treatment remains controversial. This study assessed the treatment patterns of elderly breast cancer patients. Methods Retrospective...

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Bibliographic Details
Published in:European journal of surgical oncology 2015-05, Vol.41 (5), p.625-634
Main Authors: Angarita, F.A, Chesney, T, Elser, C, Mulligan, A.M, McCready, D.R, Escallon, J
Format: Article
Language:English
Subjects:
Adjuvant therapy
Age Factors
Aged
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Antineoplastic Agents, Hormonal - therapeutic use
Breast neoplasm
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Canada
Cancer Care Facilities
Carcinoma, Ductal, Breast - metabolism
Carcinoma, Ductal, Breast - pathology
Carcinoma, Ductal, Breast - therapy
Carcinoma, Intraductal, Noninfiltrating - metabolism
Carcinoma, Intraductal, Noninfiltrating - pathology
Carcinoma, Intraductal, Noninfiltrating - therapy
Carcinoma, Lobular - metabolism
Carcinoma, Lobular - pathology
Carcinoma, Lobular - therapy
Disease-Free Survival
Female
Hematology, Oncology and Palliative Medicine
Humans
Lymph Node Excision - utilization
Mastectomy - utilization
Mastectomy, Segmental - utilization
Neoadjuvant therapy
Neoplasm Staging
Receptor, ErbB-2 - metabolism
Receptors, Estrogen - metabolism
Receptors, Progesterone - metabolism
Retrospective Studies
Surgery
Treatment outcomes
Tumor Burden
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Summary:Abstract Background Treatment of breast cancer in elderly women is limited by declining functional status and life expectancy. The impact of providing less aggressive treatment remains controversial. This study assessed the treatment patterns of elderly breast cancer patients. Methods Retrospective chart review of women ≥70 y with breast cancer treated between 2004 and 2011 at two large Canadian cancer centres. Tumour and treatment characteristics were collected across three subgroups: 70–74 y (n = 314), 75–79 y (n = 233), and ≥80 y (n = 219). Comparisons were made using Chi-squared test, Fisher-Freeman-Halton exact test, or ANOVA. Disease free (DFS) and overall (OS) survival were estimated by Kaplan–Meier analysis and compared by log-rank test. Results Women ≥80 y had larger tumours that were better differentiated, hormone receptor-positive, HER2-negative, and lymph node (LN)-positive relative to younger women (p 
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2015.01.028