Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system

We have identified, by affinity chromatography, a binding protein for the snake venom toxin taipoxin. The sequence of this 47 kDa protein is unique, is characteristic of a secreted protein, and has homology to the acute phase proteins serum amyloid P protein and C-reactive protein of the pentraxin f...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 1995-03, Vol.14 (3), p.519-526
Main Authors: Schlimgen, A.K, Helms, J.A, Vogel, H, Perin, M.S
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Brain - metabolism
C-Reactive Protein - analysis
C-Reactive Protein - biosynthesis
C-Reactive Protein - chemistry
Cerebellum - metabolism
Chromatography, Affinity
Cloning, Molecular
Elapid Venoms - metabolism
Elapid Venoms - toxicity
In Situ Hybridization
Molecular Sequence Data
Molecular Weight
Nerve Tissue Proteins - analysis
Nerve Tissue Proteins - biosynthesis
Nerve Tissue Proteins - chemistry
Neuroglia - drug effects
Neuromuscular Blocking Agents - metabolism
Neurons - metabolism
Organ Specificity
Peptide Fragments - chemistry
Peptide Fragments - isolation & purification
Rats
Recombinant Proteins - biosynthesis
Recombinant Proteins - chemistry
RNA, Messenger - analysis
RNA, Messenger - biosynthesis
Sequence Homology, Amino Acid
Serum Amyloid P-Component - chemistry
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Description
Summary:We have identified, by affinity chromatography, a binding protein for the snake venom toxin taipoxin. The sequence of this 47 kDa protein is unique, is characteristic of a secreted protein, and has homology to the acute phase proteins serum amyloid P protein and C-reactive protein of the pentraxin family. We have named this protein neuronal pentraxin (NP), as Northern analysis and in situ hybridization demonstrate high message levels in neurons of cerebellum, hippocampus, and cerebral cortex. Because NP may be released synaptically and has homology to immune proteins potentially involved in uptake of lipidic, toxic, or other antigenic material, we suggest that NP may be involved in a general uptake of synaptic macromolecules.
ISSN:0896-6273
1097-4199
DOI:10.1016/0896-6273(95)90308-9