Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats

Highlights • Short-term brain hypometabolism appeared upon pilocarpine administration in rats. • Neurodegeneration, gliosis and apoptosis were induced by pilocarpine. • Subacute fluoxetine prevented metabolic impairment induced by pilocarpine. • Brain damage markers induced by pilocarpine were reduc...

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Bibliographic Details
Published in:Brain research bulletin 2015-02, Vol.111, p.36-47
Main Authors: Shiha, Ahmed Anis, de Cristóbal, Javier, Delgado, Mercedes, Fernández de la Rosa, Rubén, Bascuñana, Pablo, Pozo, Miguel A, García-García, Luis
Format: Article
Language:English
Subjects:
[18F] FDG PET
Animals
Apoptosis - drug effects
Astrocytes - metabolism
Brain - diagnostic imaging
Brain - drug effects
Brain - metabolism
Brain hypometabolism
Caspase 3 - metabolism
Disease Models, Animal
Epilepsy
Epilepsy - chemically induced
Epilepsy - diagnostic imaging
Epilepsy - drug therapy
Epilepsy - metabolism
Fluoxetine
Fluoxetine - administration & dosage
Glucose - metabolism
Hippocampus - drug effects
Hippocampus - pathology
Lithium Chloride
Lithium-pilocarpine model
Male
Neurology
Pilocarpine
Positron-Emission Tomography
Rats
Rats, Sprague-Dawley
Receptors, GABA-A - metabolism
Serotonin
Serotonin Uptake Inhibitors - administration & dosage
Survival Analysis
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Summary:Highlights • Short-term brain hypometabolism appeared upon pilocarpine administration in rats. • Neurodegeneration, gliosis and apoptosis were induced by pilocarpine. • Subacute fluoxetine prevented metabolic impairment induced by pilocarpine. • Brain damage markers induced by pilocarpine were reduced by subacute fluoxetine. • Fluoxetine increased GABAA receptor density in rats injected with pilocarpine.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2014.12.009