Quantitative Properties of Plasma Corticosterone Elevation Induced by Naloxone-Precipitated Withdrawal in Morphine-Dependent Rats

Elevation of plasma corticosterone (PCS) has been used as an indicator of morphine withdrawal, but it is not clear whether the magnitude of elevation is related to the intensity of the dependence. The dose-dependent effects of naloxone on PCS and body weight were studied in male Sprague-Dawley rats...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1994, Vol.66(2), pp.257-263
Main Authors: Kishioka, Shiroh, Nishida, Shigeru, Fukunaga, Yuko, Yamamoto, Hiroyuki
Format: Article
Language:eng ; jpn
Subjects:
Analysis of Variance
Animals
Biological and medical sciences
Body Weight - drug effects
Body weight loss
Corticosterone - blood
Disease Models, Animal
Dose-Response Relationship, Drug
Drug toxicity and drugs side effects treatment
Injections, Subcutaneous
Male
Medical sciences
Morphine - administration & dosage
Morphine - toxicity
Morphine dependence
Morphine Dependence - blood
Naloxone - administration & dosage
Naloxone - pharmacology
Naloxone withdrawal
Pharmacology. Drug treatments
Plasma corticosterone
Rats
Rats, Sprague-Dawley
Substance Withdrawal Syndrome - blood
Toxicity: nervous system and muscle
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Summary:Elevation of plasma corticosterone (PCS) has been used as an indicator of morphine withdrawal, but it is not clear whether the magnitude of elevation is related to the intensity of the dependence. The dose-dependent effects of naloxone on PCS and body weight were studied in male Sprague-Dawley rats rendered physically dependent on morphine by injecting increasing doses of 40-120 mg/kg/day, s.c. twice daily for 1-6 days. Naloxone (0.01-2.0 mg/kg, s.c.) was administered 3 hr after the last morphine administration. Naloxone elevated PCS levels in a dose-dependent manner in all groups treated with morphine, and the elevation was correlated with the number of days of morphine treatment. Naloxone also reduced dose-dependently the body weight in all groups treated with morphine; in this case, a reverse correlation was obtained between the body weight changes and the PCS levels. It was confirmed that PCS elevation is a quantitative sign of naloxone-precipitated morphine withdrawal and that the elevation is indicative of the degree of morphine physical dependence.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.66.257