RELEASE OF PROGESTERONE AND TESTOSTERONE BY OVARIAN GRANULOSA CELLS AFTER ADDITION OF T-2 TOXIN AND ITS COMBINATION WITH GROWTH FACTOR IGF-I

The aim of the present study was to examine the effect of T-2 toxin and combination of this toxin with growth factor IGF-I on secretion of ovarian hormones progesterone P4 and testosterone by ovarian granulosa cells (GCs) of gilts. Ovarian granulosa cells were incubated withouth (control) or with tr...

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Bibliographic Details
Published in:Journal of microbiology, biotechnology and food sciences biotechnology and food sciences, 2013-01 (Special Issue 1 - Part B), p.1864-1874
Main Authors: Maruniaková, Nora, Kolesárová, Adriana, Kádasi, Attila, Medvedová, Marína, Halenár, Marek, Sirotkin, Alexander V, Grossmann, Roland, Bulla, Jozef
Format: Article
Language:English
Subjects:
Cell cycle
Growth factors
Ovaries
Testosterone
Toxicity
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Summary:The aim of the present study was to examine the effect of T-2 toxin and combination of this toxin with growth factor IGF-I on secretion of ovarian hormones progesterone P4 and testosterone by ovarian granulosa cells (GCs) of gilts. Ovarian granulosa cells were incubated withouth (control) or with treatments at various doses for 48h: T-2 toxin (10, 100 and 1000 ng.ml-1) / T-2 toxin (10,100 and 1000 ng.ml-1) plus IGF-I (100 ng.ml-1). Progesterone and testosterone were determined by RIA. Progesterone release by GCs was significantly (P
ISSN:1338-5178