Placental lesions associated with oligohydramnios in fetal growth restricted (FGR) pregnancies

Abstract Introduction Aim of the study was to investigate the association between placental pathology and oligohydramnios in pregnancies complicated by fetal growth restriction (FGR). Methods Placentas from 221 consecutive FGR pregnancies and 63 healthy controls were studied. Pathological lesions we...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2015-05, Vol.36 (5), p.538-544
Main Authors: Spinillo, A, Cesari, S, Bariselli, S, Tzialla, C, Gardella, B, Silini, E.M
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Female
Fetal growth restriction
Fetal Growth Retardation - pathology
Fetal vascular damage
Humans
Hypoxic placental injury
Internal Medicine
Obstetrics and Gynecology
Oligohydramnios
Oligohydramnios - pathology
Placenta - pathology
Preeclampsia
Pregnancy
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Summary:Abstract Introduction Aim of the study was to investigate the association between placental pathology and oligohydramnios in pregnancies complicated by fetal growth restriction (FGR). Methods Placentas from 221 consecutive FGR pregnancies and 63 healthy controls were studied. Pathological lesions were described according to consensus nomenclature and standardized criteria; both elementary lesions and constellations of lesions (patterns) were considered. Statistics included analysis of linear trends and multinomial logistic regression. Results Amniotic fluid index (AFI) was normal in 56 (25.3%) FGR pregnancies, whereas mild, moderate and severe oligohydramnios were diagnosed in 32 (14.5%), 44 (19.9%) and 89 (40.3%) subjects, respectively. In FGR pregnancies, after adjustment for potential confounders, membrane meconium staining (chi-square = 28.6, p  
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2015.02.007