Increased Risk for and Mortality From Invasive Pneumococcal Disease in HIV-Exposed but Uninfected Infants Aged <1 Year in South Africa, 2009–2013

Background. High antenatal human immunodeficiency virus (HIV) seroprevalence rates (∼30%) with low perinatal HIV transmission rates (2.5%), due to HIV prevention of mother-to-child transmission program improvements in South Africa, has resulted in increasing numbers of HIV-exposed but uninfected (HE...

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Published in:Clinical infectious diseases 2015-05, Vol.60 (9), p.1346-1356
Main Authors: von Mollendorf, Claire, von Gottberg, Anne, Tempia, Stefano, Meiring, Susan, de Gouveia, Linda, Quan, Vanessa, Lengana, Sarona, Avenant, Theunis, du Plessis, Nicolette, Eley, Brian, Finlayson, Heather, Reubenson, Gary, Moshe, Mamokgethi, O'Brien, Katherine L., Klugman, Keith P., Whitney, Cynthia G., Cohen, Cheryl
Format: Article
Language:eng
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HIV
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Summary:Background. High antenatal human immunodeficiency virus (HIV) seroprevalence rates (∼30%) with low perinatal HIV transmission rates (2.5%), due to HIV prevention of mother-to-child transmission program improvements in South Africa, has resulted in increasing numbers of HIV-exposed but uninfected (HEU) children. We aimed to describe the epidemiology of invasive pneumococcal disease (IPD) in HEU infants. Methods. We conducted a cross-sectional study of infants aged
ISSN:1058-4838
1537-6591