The Portuguese version of Addenbrooke's Cognitive Examination-Revised (ACE-R) in the diagnosis of subcortical vascular dementia and Alzheimer's disease

The aim of this study was to investigate the accuracy of the Portuguese version of Addenbrooke's Cognitive Examination-Revised (ACE-R) in detecting and differentiating early stage subcortical vascular dementia (SVD) from early stage Alzheimer's disease (AD). Ninety-two subjects (18 SVD pat...

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Bibliographic Details
Published in:Aging, Neuropsychology, and Cognition Neuropsychology, and Cognition, 2015-07, Vol.22 (4), p.473-485
Main Authors: Gonçalves, Cátia, Pinho, Maria Salomé, Cruz, Vitor, Pais, Joana, Gens, Helena, Oliveira, Fátima, Santana, Isabel, Rente, José, Santos, José Manuel
Format: Article
Language:English
Subjects:
Addenbrooke's Cognitive Examination-Revised
Aged
Alzheimer Disease - diagnosis
Alzheimer's disease
dementia
Dementia, Vascular - diagnosis
Female
Humans
Male
Neuropsychological Tests
Portugal
Reproducibility of Results
ROC Curve
screening
subcortical vascular dementia
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Summary:The aim of this study was to investigate the accuracy of the Portuguese version of Addenbrooke's Cognitive Examination-Revised (ACE-R) in detecting and differentiating early stage subcortical vascular dementia (SVD) from early stage Alzheimer's disease (AD). Ninety-two subjects (18 SVD patients, 36 AD patients, and 38 healthy controls) were assessed using the ACE-R. Between-group's differences were evaluated using the Quade's rank analysis of covariance. The diagnostic accuracy and discriminatory ability of the ACE-R were examined via receiver operating characteristic (ROC) analysis. The ACE-R was able to successfully discriminate between patients and healthy subjects. The mean ACE-R total scores differed between SVD and AD patients; there were also significant differences in attention and orientation and in memory measures between the groups. An optimal cut-off of 72/73 was found for the detection of AD (sensitivity: 97%; specificity: 92%) and SVD (sensitivity: 100%; specificity: 92%).
ISSN:1382-5585
1744-4128
DOI:10.1080/13825585.2014.984652