Gender influences the relationship between lung function and cardiac remodeling in hypertensive subjects

Hypertensive patients are predisposed to left ventricular (LV) remodeling and frequently exhibit decline in lung function as compared with the general population. Here, we investigated the association between spirometric and echocardiographic data in non-smoking hypertensive subjects and the role of...

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Bibliographic Details
Published in:Hypertension research 2015-04, Vol.38 (4), p.264-268
Main Authors: Mendes, Paulo R, Kiyota, Tatiana A, Cipolli, José A, Schreiber, Roberto, Paim, Layde R, Bellinazzi, Vera R, Matos-Souza, José R, Sposito, Andrei C, Nadruz, Jr, Wilson
Format: Article
Language:English
Subjects:
Adult
Aged
Atrial Function, Left
Cardiovascular system
Cross-Sectional Studies
Echocardiography
Female
Forced Expiratory Volume
Gender differences
Humans
Hypertension
Hypertension - physiopathology
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - etiology
Hypertrophy, Left Ventricular - physiopathology
Lung - physiopathology
Lungs
Male
Middle Aged
Sex Characteristics
Spirometry
Ultrasonic imaging
Ventricular Remodeling
Vital Capacity
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Summary:Hypertensive patients are predisposed to left ventricular (LV) remodeling and frequently exhibit decline in lung function as compared with the general population. Here, we investigated the association between spirometric and echocardiographic data in non-smoking hypertensive subjects and the role of gender in this regard. In a cross-sectional study, 107 hypertensive patients (60 women) enrolled from a university outpatient clinic were evaluated by clinical, hemodynamic, laboratory and echocardiographic analysis. Vital capacity, forced vital capacity (FVC), forced expired volume in 1 s (FEV1) and in 6 s (FEV6), FEV1/FVC ratio and FEV1/FEV6 ratio were estimated by spirometry. In women, higher LV mass index and E/Em ratio correlated with markers of restrictive lung alterations, such as reduced FVC (r=-044; P
ISSN:0916-9636
1348-4214
DOI:10.1038/hr.2014.168