Newtonian and non-Newtonian blood flow in coiled cerebral aneurysms

Abstract Endovascular coiling aims to isolate the aneurysm from blood circulation by altering hemodynamics inside the aneurysm and triggering blood coagulation. Computational fluid dynamics (CFD) techniques have the potential to predict the post-operative hemodynamics and to investigate the complex...

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Bibliographic Details
Published in:Journal of biomechanics 2013-09, Vol.46 (13), p.2158-2164
Main Authors: Morales, Hernán G, Larrabide, Ignacio, Geers, Arjan J, Aguilar, Martha L, Frangi, Alejandro F
Format: Article
Language:English
Subjects:
Aneurysms
Blood flow
Blood Viscosity
Cerebral aneurysms
Cerebrovascular Circulation
CFD
Coiling
Computational fluid dynamics
Computer simulation
Endovascular coiling
Fluid dynamics
Heat transfer
Hemodynamics
Humans
Intracranial Aneurysm - blood
Intracranial Aneurysm - physiopathology
Mathematical models
Models, Cardiovascular
Newtonian fluids
Non-Newtonian fluid flow
Physical Medicine and Rehabilitation
Shear strain
Studies
Viscosity
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Summary:Abstract Endovascular coiling aims to isolate the aneurysm from blood circulation by altering hemodynamics inside the aneurysm and triggering blood coagulation. Computational fluid dynamics (CFD) techniques have the potential to predict the post-operative hemodynamics and to investigate the complex interaction between blood flow and coils. The purpose of this work is to study the influence of blood viscosity on hemodynamics in coiled aneurysms. Three image-based aneurysm models were used. Each case was virtually coiled with a packing density of around 30%. CFD simulations were performed in coiled and untreated aneurysm geometries using a Newtonian and a Non-Newtonian fluid models. Newtonian fluid slightly overestimates the intra-aneurysmal velocity inside the aneurysm before and after coiling. There were numerical differences between fluid models on velocity magnitudes in coiled simulations. Moreover, the non-Newtonian fluid model produces high viscosity ( > 0.007 [Pa s]) at aneurysm fundus after coiling. Nonetheless, these local differences and high-viscous regions were not sufficient to alter the main flow patterns and velocity magnitudes before and after coiling. To evaluate the influence of coiling on intra-aneurysmal hemodynamics, the assumption of a Newtonian fluid can be used.
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2013.06.034