Enhanced mechanical properties and bone bioactivity of chitosan/silica membrane by functionalized-carbon nanotube incorporation

A space-maintaining ability of degradable guided bone regeneration (GBR) membranes is still a challenge due to weak mechanical strength despite their excellent concept. Here we incorporated functionalized-carbon nanotube (f-CNT) for this purpose. In particular, a hybrid composition of chitosan/silic...

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Bibliographic Details
Published in:Composites science and technology 2014-05, Vol.96, p.31-37
Main Authors: Seo, Seog-Jin, Kim, Jung-Ju, Kim, Joong-Hyun, Lee, Ja-Yeon, Shin, Ueon Sang, Lee, Eun-Jung, Kim, Hae-Won
Format: Article
Language:English
Subjects:
A. Carbon nanotubes
A. Hybrid composites
Applied sciences
B. Mechanical properties
Biochemistry
Biological and medical sciences
Bones
Chitosan
Composites
Degradation
E. Sol–gel methods
Exact sciences and technology
Forms of application and semi-finished materials
Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics
Maxillofacial surgery. Dental surgery. Orthodontics
Mechanical properties
Medical sciences
Membranes
Nanostructure
Polymer industry, paints, wood
Silicon
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology of polymers
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Summary:A space-maintaining ability of degradable guided bone regeneration (GBR) membranes is still a challenge due to weak mechanical strength despite their excellent concept. Here we incorporated functionalized-carbon nanotube (f-CNT) for this purpose. In particular, a hybrid composition of chitosan/silica (CS/Si) was used as the matrix of the GBR membrane. With increasing f-CNT content, hydrophilic nature increased while hydrolytic degradability was reduced. Among the membranes with various contents of f-CNT (up to 3 wt%), 2wt% f-CNT-doped CS/Si showed the highest mechanical properties, including tensile strength and elastic modulus as well as significantly improved bone bioactivity with respect to CS/Si free of f-CNT. In vivo animal study showed favorable tissue responses of the CNT-incorporated membrane. Taken all, the newly-developed CNT/CS/Si may find potential usefulness as a GBR membrane with excellent mechanical properties while exhibiting good bioactivity and tissue reaction.
ISSN:0266-3538
1879-1050
DOI:10.1016/j.compscitech.2014.03.004