Synthesis of cyclodextrin-reduced graphene oxide hybrid nanosheets for sensitivity enhanced electrochemical determination of diethylstilbestrol

► β-CD-RGO hybrid nanosheets were successfully prepared by using l-AA as the reducing agent under a mild condition. ► β-CD-RGO/GCE greatly enhanced the electrochemical response of diethylstilbestrol (DES). ► DES can be detected with wide linear range and a low detection limit. ► β-CD-RGO/GCE can be...

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Bibliographic Details
Published in:Electrochimica acta 2012-12, Vol.85, p.131-138
Main Authors: Lu, Daban, Lin, Shaoxiong, Wang, Letao, Shi, Xuezhao, Wang, Chunming, Zhang, Yan
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
Chemistry
Determination
Diethylstilbestrol
Electrochemistry
Electrodes
Exact sciences and technology
General and physical chemistry
General aspects
Glassy carbon
Graphene
l-Ascorbic acid
Medical sciences
Milk
Nanocomposites
Nanomaterials
Nanostructure
Optimization
Oxides
Pharmacology. Drug treatments
Recognition
Reproducibility
β-Cyclodextrin
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Summary:► β-CD-RGO hybrid nanosheets were successfully prepared by using l-AA as the reducing agent under a mild condition. ► β-CD-RGO/GCE greatly enhanced the electrochemical response of diethylstilbestrol (DES). ► DES can be detected with wide linear range and a low detection limit. ► β-CD-RGO/GCE can be applied in real milk samples analysis with satisfactory results. β-Cyclodextrin functionalized reduced graphene oxide hybrid nanosheets (β-CD-RGO) were successfully prepared by using l-ascorbic acid (l-AA) as the reducing agent under a mild condition and used as enhanced material for sensitivity determination of diethylstilbestrol (DES). In 0.1M PBS (pH 7.0), the redox peak currents of DES increased significantly on β-CD-RGO modified glassy carbon electrode (β-CD-RGO/GCE), suggesting that the composite film not only shows excellent electronic properties of RGO sheets but also exhibits high supramolecular recognition capability of β-CD. The experimental conditions were optimized and the kinetic parameters were investigated. Under the optimal conditions, the reduction peak current of DES increased linearly with increasing the concentration in the range from 0.01 to 13μM with the detection limit of 4nM (S/N=3). The developed electrochemical sensor exhibited high selectivity, good stability and reproducibility, and also successfully determined DES in milk samples with satisfactory results.
ISSN:0013-4686
1873-3859
DOI:10.1016/j.electacta.2012.07.071