Edible Oils for Liver Protection: Hepatoprotective Potentiality of Moringa Oleifera Seed Oil against Chemical-Induced Hepatitis in Rats

:  In the present study, in vitro antioxidant, antioxidative stress and hepatoprotective activity of Moringa oleifera Lam. seed oil (Ben oil; BO) was evaluated against carbon tetrachloride (CCl4) induced lipid peroxidation and hepatic damage in rats. The oil at 0.2 and 0.4 mL/rat was administered or...

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Bibliographic Details
Published in:Journal of food science 2012-07, Vol.77 (7), p.T124-T130
Main Authors: Al-Said, Mansour S., Mothana, Ramzi A., Al-Yahya, Mohammed A., Al-Blowi, Ali S., Al-Sohaibani, Mohammed, Ahmed, Atallah F., Rafatullah, Syed
Format: Article
Language:English
Subjects:
Animals
antioxidant
Antioxidants
Antioxidants - pharmacology
Beneficiation
beta Carotene - analysis
Bilirubin - blood
Biological and medical sciences
Biphenyl Compounds - pharmacology
Carbon tetrachloride
Carbon Tetrachloride Poisoning - pathology
Carbon Tetrachloride Poisoning - prevention & control
Chemical and Drug Induced Liver Injury - drug therapy
Chemical and Drug Induced Liver Injury - pathology
Chemicals
Damage
Fat industries
Female
Flowers & plants
Food industries
Fundamental and applied biological sciences. Psychology
Hepatitis
hepatoprotective
In vitro testing
Linoleic Acid - analysis
lipid peroxidation
Lipid Peroxidation - drug effects
Liver
Liver - drug effects
Liver - pathology
Male
Malondialdehyde - blood
Mice
Moringa oleifera
Moringa oleifera - chemistry
Oils & fats
Oxidative stress
Picrates - pharmacology
Plant Oils - pharmacology
Rats
Rats, Wistar
Scavenging
Seeds - chemistry
Silymarin - pharmacology
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Summary::  In the present study, in vitro antioxidant, antioxidative stress and hepatoprotective activity of Moringa oleifera Lam. seed oil (Ben oil; BO) was evaluated against carbon tetrachloride (CCl4) induced lipid peroxidation and hepatic damage in rats. The oil at 0.2 and 0.4 mL/rat was administered orally for 21 consecutive days. The substantially elevated serum enzymatic (GOT, GPT, ALP, GGT) and bilirubin levels were significantly restored towards normalization by the oil. There was a significant elevation in the level of malondialdehyde (MDA), non‐protein sulfhydryl (NP‐SH), and total protein (TP) contents in the liver tissue. The results obtained indicated that BO possesses potent hepatoprotective action against CCl4‐induced hepatic damage by lowering liver marker enzymes, MDA concentration, and elevating NP‐SH and TP levels in liver tissue. The biochemical observations were supplemented with histopathological examination of rat liver. The results of this study showed that treatment with Ben oil or silymarin (as a reference) appears to enhance the recovery from hepatic damage induced by CCl4. The pentobarbital induced narcolepsy prolongation in mice was retarded by the Ben oil. Acute toxicity test in mice showed no morbidity or mortality. In vitro DPPH radical scavenging and β‐carotene‐linolic acid assay tests of the BO exhibited a moderate antioxidant activity in both tests used. The possible mechanism(s) of the liver protective activity of Ben oil activity may be due to free radical scavenging potential caused by the presence of antioxidant component(s) in the oil. Consequently, BO can be used as a therapeutic regime in treatment of some hepatic disorders.
ISSN:0022-1147
1750-3841
DOI:10.1111/j.1750-3841.2012.02698.x