Study of the chemical chelates and anti-microbial effect of some metal ions in nanostructural form on the efficiency of antibiotic therapy “norfloxacin drug”

► La2O3 and CeO2 nano-particles were prepared using urea as precursors. ► norH ligand, official and nano-particles of lanthanide complexes were screened against their antimicrobial. ► Nano-particles complexes have more biological potent than the free norH and normal lanthanide complexes. This paper...

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Bibliographic Details
Published in:Journal of molecular structure 2012-04, Vol.1013, p.45-54
Main Authors: Refat, Moamen S., El-Hawary, W.F., Mohamed, Mahmoud A.
Format: Article
Language:English
Subjects:
Anti-microbial
antibiotics
antifungal properties
Antiinfectives and antibacterials
Aspergillus flavus
Bacillus subtilis
Biological evaluation
Candida albicans
cerium
chelates
electrical conductivity
Escherichia coli
ions
Lanthanide(III) metals
Lanthanides
lanthanum
metal ions
Nano-particles
Nanocomposites
Nanomaterials
nanoparticles
Nanostructure
Norfloxacin
oxygen
Oxygen atoms
Pseudomonas aeruginosa
Scanning electron microscopy
Staphylococcus aureus
therapeutics
thermal analysis
urea
X-radiation
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Summary:► La2O3 and CeO2 nano-particles were prepared using urea as precursors. ► norH ligand, official and nano-particles of lanthanide complexes were screened against their antimicrobial. ► Nano-particles complexes have more biological potent than the free norH and normal lanthanide complexes. This paper has reviewed the chemical and biological impact resulting from the interaction between norfloxacin (norH) antibiotic drug and two lanthanide (lanthanum(III) and cerium(III)) metal ions, which prepared in normal and nano-features. La(III) and Ce(III) complexes were synthesized with chemical formulas [La(nor)3]·3H2O and [Ce(nor)3]·2H2O. Lanthanum and cerium(III) ions coordinated toward norH with a hexadentate geometry. The norH acts as deprotonated bidentate ligand through the oxygen atom of carbonyl group and the oxygen atom of carboxylic group. Elemental analysis, FT-IR spectral, electrical conductivity, thermal analysis (TG/DTA), X-ray powder diffraction (XRD) and scanning electron microscopy (SEM) measurements have been used to characterize the mentioned isolated complexes. The Coats–Redfern and Horowitz–Metzger integral methods are used to estimate the kinetic parameters for the major successive steps detectable in the TG curve. The brightness side in this study is to take advantage for the preparation and characterization of single phases of La2O3 and CeO2 nanoparticles using urea as precursors via a solid-state decomposition procedure. The norH ligand in comparison with both cases (normal and nano-particles) of lanthanide complexes were screened against for antibacterial (Escherichia Coli, Staphylococcus Aureus, Bacillus subtilis and Pseudomonas aeruginosa) and antifungal (Aspergillus Flavus and Candida Albicans) activities. The highest antibacterial and antifungal activities data of the nano-particles complexes were observed with more potent than the free norH and normal lanthanide complexes.
ISSN:0022-2860
1872-8014
DOI:10.1016/j.molstruc.2011.12.010