Astrocytic NDRG2 is involved in glucocorticoid-mediated diabetic mechanical allodynia

Highlights • Activation of SDH astrocytes plays a vital role in diabetic mechanical allodynia. • Glucocorticoids contribute to diabetic tactile allodynia partly via SDH astrocytes. • NDRG2 is involved in glucocorticoid-induced activation of SDH astrocytes. • This work extends glucocorticoid-induced...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2015-04, Vol.108 (1), p.128-136
Main Authors: Zuo, Zhong-Fu, Liao, Yong-Hui, Ding, Tan, Dong, Yu-Lin, Qu, Juan, Wang, Jian, Wei, Yan-Yan, Lu, Ya-Cheng, Liu, Xue-Zheng, Li, Yun-Qing
Format: Article
Language:English
Subjects:
Animals
Astrocytes
Astrocytes - drug effects
Astrocytes - metabolism
Blotting, Western
Diabetes Mellitus, Experimental - complications
Diabetes Mellitus, Experimental - metabolism
Diabetic mechanical allodynia
Endocrinology & Metabolism
Glucocorticoids
Glucocorticoids - pharmacology
Hyperalgesia - drug therapy
Hyperalgesia - etiology
Hyperalgesia - metabolism
Immunohistochemistry
Male
NDRG2
Nerve Tissue Proteins - biosynthesis
Rats
Rats, Sprague-Dawley
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Summary:Highlights • Activation of SDH astrocytes plays a vital role in diabetic mechanical allodynia. • Glucocorticoids contribute to diabetic tactile allodynia partly via SDH astrocytes. • NDRG2 is involved in glucocorticoid-induced activation of SDH astrocytes. • This work extends glucocorticoid-induced diabetic allodynia from neuron to astrocyte.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2015.01.023