Development of a more specific and accurate multiple reaction monitoring method based on GC–EI/MS/MS for simultaneously monitoring and determining 34 kinds of pesticides in Qianjinzhidai pills

•Thirty-four kinds of pesticides were monitored and determined by GC–EI/MS/MS.•A novel optimization method about ion transitions was provided.•This method can enhance the specificity of mass spectrum monitoring.•This method can improve the accuracy of content determination. A rapid and accurate mult...

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Bibliographic Details
Published in:Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2015-03, Vol.983-984, p.47-54
Main Authors: Jiang, Yunbin, Zhong, Mei, Gou, Yan, Peng, Wei, Zhou, Juan, Wu, Pie, Ma, Yuying
Format: Article
Language:English
Subjects:
Analytic Sample Preparation Methods
Calibration
Content determination
Drugs, Chinese Herbal - chemistry
Gas Chromatography-Mass Spectrometry - methods
GC–EI/MS/MS
Ion transitions
Limit of Detection
Linearity
Monitoring
Monitors
Pesticide residues
Pesticides
Pesticides - analysis
Pills
Qianjinzhidai pills
Reference Standards
Repeatability
Reproducibility
Reproducibility of Results
Spectrometry, Mass, Electrospray Ionization - methods
Stability
Traditional chinese medicine
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Summary:•Thirty-four kinds of pesticides were monitored and determined by GC–EI/MS/MS.•A novel optimization method about ion transitions was provided.•This method can enhance the specificity of mass spectrum monitoring.•This method can improve the accuracy of content determination. A rapid and accurate multi-residue method was developed for simultaneously monitoring and determining 34 kinds of pesticides by GC–EI/MS/MS, successfully applied in Qianjinzhidai pills. Precision, repeatability, stability, limit of detection (LOD), limit of quantification (LOQ), linearity range and accuracy tests were used to validate this method. The results, precision (RSD
ISSN:1570-0232
1873-376X
DOI:10.1016/j.jchromb.2015.01.002