The effect of temperature on the effects of the phospholipase A2 neurotoxins β-bungarotoxin and taipoxin at the neuromuscular junction

Snake venom neurotoxins with phospholipase A2 affect the neuromuscular junction with three distinct phases. There is a transient decrease in twitch height, followed by a facilitatory phase and finally a progressive blockade. It has been suggested that the initial phase is a direct consequence of the...

Full description

Saved in:
Bibliographic Details
Published in:Toxicon (Oxford) 2013-08, Vol.70, p.86-89
Main Authors: Fathi, Behrooz, Harvey, Alan L., Rowan, Edward G.
Format: Article
Language:English
Subjects:
Animals
Binding
Blocking
Bungarotoxins - toxicity
Elapid Venoms - toxicity
enzyme activity
Exposure
Male
Mice
Mice, Inbred BALB C
Neuromuscular junction
Neuromuscular Junction - drug effects
Neuromuscular Junction - metabolism
neurotoxins
Neurotoxins - toxicity
Phases
Phospholipase
phospholipase A2
Phospholipase A2 Inhibitors - toxicity
Phospholipase A2 neurotoxins
Snakes
Taipoxin
Temperature
Terminals
Three phase
Toxins
venoms
β-Bungarotoxin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Snake venom neurotoxins with phospholipase A2 affect the neuromuscular junction with three distinct phases. There is a transient decrease in twitch height, followed by a facilitatory phase and finally a progressive blockade. It has been suggested that the initial phase is a direct consequence of the binding of the toxins to nerve terminals. This study was designed to determine whether the initial phase is present under conditions that would reduce the enzyme activity of the toxins. At 27 °C, β-bungarotoxin and taipoxin exhibited all three phases, i.e. 5–6 min after exposure to the preparation, twitch height was significantly reduced (P 
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2013.04.016