Influence of the consumption of meat contaminated with anabolic steroids on doping tests

In 1989, 3 cases out of 20 were found where gas chromatography—mass spectrometry revealed the presence of nandrolone metabolites in the urine of untreated persons. Although the origin of the nandrolone metabolites was uncertain at that time, the presumption was that such findings could be related to...

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Bibliographic Details
Published in:Analytica chimica acta 1993-04, Vol.275 (1), p.49-56
Main Authors: Debruyckere, G., Van Peteghem, C.H., de Sagher, R.
Format: Article
Language:English
Subjects:
Anabolic steroids
Biological and medical sciences
Clostebol
Doping
Drug intoxications. Doping
Gas chromatography
Mass spectrometry
Meat
Medical sciences
Nandrolone
Pharmacology. Drug treatments
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Summary:In 1989, 3 cases out of 20 were found where gas chromatography—mass spectrometry revealed the presence of nandrolone metabolites in the urine of untreated persons. Although the origin of the nandrolone metabolites was uncertain at that time, the presumption was that such findings could be related to the consumption of meat from nandrolone-treated animals. Two years later, in a feeding experiment with volunteers, 1 out of 10 persons was positive for clostebol due to the accidental consumption of meat contaminated with clostebol acetate. In 1992, a similar random experiment was carried out ( n = 50), yielding 2 positive cases (1 nandrolone case and 1 clostebol case). The urinary concentrations found in the volunteers who had accidentally consumed contaminated meat were compared with the levels found in volunteers after a controlled intake of a minor dose of the anabolic steroid concerned. The above levels were also compared with those after intake of a therapeutic dose of the compound.
ISSN:0003-2670
1873-4324
DOI:10.1016/0003-2670(93)80275-P