In vitro antiviral activity of seeds from Guettarda angelica against avian viruses

The aim of this study was to evaluate the inhibition of the aqueous extract of seeds (AEs) from Guettarda angelica on cell infection by two avian RNA viruses: avian reovirus (ARV) and metapneumovirus (AMPV). The cytotoxic and antiviral activities were evaluated by MTT assay to determine the 50% cyto...

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Bibliographic Details
Published in:Journal of applied pharmaceutical science 2013-07, Vol.3 (7), p.31-033
Main Authors: Barros, Alyne Vieira, da Conceicao, Aline Oliveira, Simoni, Isabela Cristina, Padilla, Marina Aiello, Fernandes, Maria Judite Bittencourt, Arns, Clarice Weis
Format: Article
Language:English
Subjects:
Angelica
Avian reovirus
Guettarda
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Summary:The aim of this study was to evaluate the inhibition of the aqueous extract of seeds (AEs) from Guettarda angelica on cell infection by two avian RNA viruses: avian reovirus (ARV) and metapneumovirus (AMPV). The cytotoxic and antiviral activities were evaluated by MTT assay to determine the 50% cytotoxic (CC50) and inhibitory concentrations (IC50). The selectivity index (SI=CC50/IC50) also carried out. AEs exhibited antiviral activity only against ARV presenting IC50 of 23.59A mu g/mL. This inhibition was not due to any cytotoxic effect of AEs since the CC50 on Vero cells was of 400.60A mu g/mL and its SI was of 17.00; this extract also showed a virucidal effect on ARV. Previous studies also demonstrated antiviral activity of AEs extract against three animal herpesviruses. Thus, the seeds from G. angelica showing antiviral activity against DNA and RNA viruses, enveloped and non-enveloped, could be promising source of new antiviral agents encouraging its fractionation to isolate the active compound.
ISSN:2231-3354
DOI:10.7324/JAPS.2013.3706