Intravenous Ketogenic Diet Therapy for Treatment of the Acute Stage of Super-Refractory Status Epilepticus in a Pediatric Patient

Abstract Background A ketogenic diet has been used successfully to treat intractable epilepsy. However, the role of early intravenous initiation of ketogenic diet in the acute phase of super-refractory status epilepticus is not well-described. Methods An intravenous ketogenic diet was administered t...

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Bibliographic Details
Published in:Pediatric neurology 2015-04, Vol.52 (4), p.442-445
Main Authors: Lin, Jainn-Jim, MD, Lin, Kuang-Lin, MD, Chan, Oi-Wa, MD, Hsia, Shao-Hsuan, MD, Wang, Huei-Shyong, MD
Format: Article
Language:English
Subjects:
Acute Disease
Administration, Intravenous
Anesthetics, Intravenous - therapeutic use
Child
children
Diet, Ketogenic - adverse effects
Drug Resistant Epilepsy - diet therapy
Humans
intravenous ketogenic diet
ketogenic diet
Ketosis - etiology
Male
Neurology
Pediatrics
refractory status epilepticus
Status Epilepticus - diet therapy
Thiamylal - therapeutic use
Treatment Outcome
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Summary:Abstract Background A ketogenic diet has been used successfully to treat intractable epilepsy. However, the role of early intravenous initiation of ketogenic diet in the acute phase of super-refractory status epilepticus is not well-described. Methods An intravenous ketogenic diet was administered to a boy with super-refractory status epilepticus. At 24 hours after intravenous ketogenic diet, moderate ketosis appeared, and thiamylal was successfully weaned at 70 hours after admission. Results An intravenous ketogenic regimen led to subsequent ketosis and seizure control in a child with super-refractory status epilepticus. Conclusion Early induction of ketosis may be a novel strategy to effectively treat super-refractory status epilepticus. Although there are few data regarding the early use of intravenous ketogenic diet in the treatment of super-refractory status epilepticus, it may be considered an alternative option.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2014.12.008