Impaired immune response to Candida albicans in cells from Fanconi anemia patients

•Fanconi anemia (FA) cells show a defective response to Candida albicans.•C. albicans induce reduced production of IL-1β in FA compared to controls.•C. albicans do not induce production of TNF-α and IL-17 in FA cells. Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and...

Full description

Saved in:
Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2015-05, Vol.73 (1), p.203-207
Main Authors: Parodi, Alessia, Kalli, Francesca, Svahn, Johanna, Stroppiana, Giorgia, De Rocco, Daniela, Terranova, Paola, Dufour, Carlo, Fenoglio, Daniela, Cappelli, Enrico
Format: Article
Language:English
Subjects:
Adolescent
Candida albicans
Candida albicans - immunology
CD8-Positive T-Lymphocytes - immunology
Cell Proliferation
Cells, Cultured
Child
Child, Preschool
Cytokines - biosynthesis
Fanconi anemia
Fanconi Anemia - immunology
Fanconi Anemia - microbiology
Fanconi Anemia - pathology
Humans
IL-17
IL-1β
Immunity
Infant
TNF-α
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Fanconi anemia (FA) cells show a defective response to Candida albicans.•C. albicans induce reduced production of IL-1β in FA compared to controls.•C. albicans do not induce production of TNF-α and IL-17 in FA cells. Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and cancer predisposition. Several studies show alterations of the immunological status of FA patients including defects in peripheral blood lymphocyte subsets, serum immunoglobulin levels, and inflammatory cytokines. However scanty information is available on the response of FA cells to specific infectious antigens. In this work we examined the response of FA cells to different immunological stimuli and found a defective response of IL-1β, TNF-α and IL-17 to Candida albicans stimulation thus pointing to a potentially impaired response to fungal infections of FA patients.
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2015.02.016