Analysis of B-Cell Subpopulations in Monoclonal Gammopathies

Micro-Abstract To clarify the pathophysiology of multiple myeloma (MM) it is necessary to investigate the various developmental stages of B-cells. We provide a detailed phenotypic profile and enumeration of B-cell subpopulations in monoclonal gammopathy patients. A reduction of B-cells and different...

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Bibliographic Details
Published in:Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2015-04, Vol.15 (4), p.e61-e71
Main Authors: Všianská, Pavla, Říhová, Lucie, Varmužová, Tamara, Suská, Renata, Kryukov, Fedor, Mikulášová, Aneta, Kupská, Renata, Penka, Miroslav, Pour, Luděk, Adam, Zdeněk, Hájek, Roman
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antigens, Surface - metabolism
B-cell
B-Lymphocyte Subsets - metabolism
B-Lymphocyte Subsets - pathology
Chromosome Aberrations
Diagnosis, Differential
Female
Flow Cytometry
Hematology, Oncology and Palliative Medicine
Humans
Immunophenotyping
Male
Middle Aged
Monoclonal Gammopathy
Monoclonal Gammopathy of Undetermined Significance - diagnosis
Monoclonal Gammopathy of Undetermined Significance - genetics
Monoclonal Gammopathy of Undetermined Significance - metabolism
Multiple Myeloma
Multiple Myeloma - diagnosis
Multiple Myeloma - genetics
Multiple Myeloma - metabolism
Paraproteinemias - diagnosis
Paraproteinemias - genetics
Paraproteinemias - metabolism
Phenotype
Plasma Cell
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Summary:Micro-Abstract To clarify the pathophysiology of multiple myeloma (MM) it is necessary to investigate the various developmental stages of B-cells. We provide a detailed phenotypic profile and enumeration of B-cell subpopulations in monoclonal gammopathy patients. A reduction of B-cells and differentiation shift to more numerous antigen-stimulated forms was observed in MM. This might indicate a potential source of myeloma-initiating cells in one of these subpopulations.
ISSN:2152-2650
2152-2669
DOI:10.1016/j.clml.2014.12.003