Clinical findings and outcomes in patients with possible usual interstitial pneumonia

Summary Background Patients with possible usual interstitial pneumonia (UIP) constitute a substantial group, and their clinical characteristics and outcomes are not well defined. We compared the clinical characteristics and survival between patients with possible UIP and the UIP pattern. Methods We...

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Bibliographic Details
Published in:Respiratory medicine 2015-04, Vol.109 (4), p.510-516
Main Authors: Lee, Jin Wook, Shehu, Esmeralda, Gjonbrataj, Juarda, Bahn, Young Eun, Rho, Byung Hak, Lee, Mi-Young, Choi, Won-Il
Format: Article
Language:English
Subjects:
Age
Aged
Biopsy
Carbon monoxide
Carbon Monoxide - chemistry
Carbon Monoxide - metabolism
Case-Control Studies
Demography
Diagnosis, Differential
Disease
Facilitated Diffusion
Female
HRCT
Humans
Idiopathic pulmonary fibrosis
Idiopathic Pulmonary Fibrosis - diagnosis
Idiopathic Pulmonary Fibrosis - epidemiology
Idiopathic Pulmonary Fibrosis - physiopathology
Lung - diagnostic imaging
Male
Medical imaging
Medical prognosis
Middle Aged
Mortality
Multivariate Analysis
Prognosis
Propensity Score
Pulmonary fibrosis
Pulmonary/Respiratory
Republic of Korea - epidemiology
Respiratory Function Tests - methods
Respiratory Function Tests - statistics & numerical data
Retrospective Studies
Review boards
Survival Rate
Tomography, X-Ray Computed - methods
Variables
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Summary:Summary Background Patients with possible usual interstitial pneumonia (UIP) constitute a substantial group, and their clinical characteristics and outcomes are not well defined. We compared the clinical characteristics and survival between patients with possible UIP and the UIP pattern. Methods We evaluated 62 patients with possible UIP and 544 patients with the UIP pattern. Both groups were diagnosed by clinical characteristics and high-resolution computed tomography (HRCT) findings. Two radiologists performed radiological evaluation based on the new idiopathic pulmonary fibrosis (IPF) guidelines. Two risk-stratification methods were used to compare UIP pattern and possible UIP patients. Results The groups had similar demographic and clinical characteristics. Pulmonary function tests revealed no significant differences in lung volumes between the 2 groups. However, DLCO was significantly lower with the UIP pattern than with possible UIP ( p  = 0.004). Multivariate analysis showed age, sex, and carbon monoxide diffusing capacity (DLCO) as important independent variables for survival. The UIP HRCT pattern did not affect survival (hazard ratio, 0.83; 95% confidence interval, 0.51–1.24; p  = 0.32). Possible UIP was not associated with prognosis when independent predictors for survival rate and propensity score were considered. In the case-control study, the 3-year survival rate was 44.6% in the UIP pattern group and 56.8% in the possible UIP group ( p  = 0.16). Conclusions Clinical characteristics and outcomes were similar in possible UIP and UIP patients, except for differences in DLCO. The UIP pattern itself did not affect survival.
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2015.02.008