Piceatannol inhibits effector T cell functions by suppressing TcR signaling

Piceatannol, a metabolite of resveratrol found in red wine and grapes, displays a wide spectrum of biological activity. Although the anti-oxidant, anti-inflammatory, and anti-tumorigenesis activity of piceatannol has been extensively studied, its role in the adaptive immune response has received les...

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Bibliographic Details
Published in:International immunopharmacology 2015-04, Vol.25 (2), p.285-292
Main Authors: Kim, Do-Hyun, Lee, Yong-Gab, Park, Hong-Jai, Lee, Jung-Ah, Kim, Hyun Jung, Hwang, Jae-Kwan, Choi, Je-Min
Format: Article
Language:English
Subjects:
Animals
Antigens, CD - metabolism
Antigens, Differentiation, T-Lymphocyte - metabolism
CD4-Positive T-Lymphocytes - cytology
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - metabolism
CD8-Positive T-Lymphocytes - drug effects
CD8-Positive T-Lymphocytes - metabolism
Cell Differentiation - drug effects
Cytokines - metabolism
Female
Interleukin-2 Receptor alpha Subunit - metabolism
Lectins, C-Type - metabolism
Mice, Inbred C57BL
Mitogen-Activated Protein Kinases - antagonists & inhibitors
Mitogen-Activated Protein Kinases - metabolism
Phosphorylation - drug effects
Piceatannol
Protein Kinase Inhibitors - pharmacology
Receptors, Antigen, T-Cell - metabolism
Spleen - cytology
Stilbenes - pharmacology
T cell differentiation
T cell proliferation
T cells
TcR signaling
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Summary:Piceatannol, a metabolite of resveratrol found in red wine and grapes, displays a wide spectrum of biological activity. Although the anti-oxidant, anti-inflammatory, and anti-tumorigenesis activity of piceatannol has been extensively studied, its role in the adaptive immune response has received less attention. Here we investigated the role of piceatannol, a well-known Syk inhibitor, in T cell activation, proliferation, and differentiation using isolated murine splenic T cells from C57BL/6 mice. Piceatannol treatment inhibited surface expression of CD4 and CD8 T cell activation markers CD25 and CD69, reduced production of cytokines IFNγ, IL-2, and IL-17, and suppressed proliferation of activated T cells. Moreover, piceatannol treatment significantly inhibited differentiation of CD4+CD25−CD62L+ naïve CD4 T cells into Th1, Th2, and Th17 cells, presumably due to inhibition of TcR signaling through p-Erk, p-Akt, and p-p38. Piceatannol appears to be a useful nutritional or pharmacological biomolecule that regulates effector T cell functions such as cytokine production, differentiation, and proliferation. [Display omitted] •Piceatannol inhibits expression of activation markers CD25 and CD69 in CD4 and CD8 T cells.•Piceatannol suppresses cytokine production and proliferation in activated T cells.•Piceatannol negatively regulates effector T cell differentiation including Th1, Th2, and Th17.•Piceatannol reduces phosphorylation of Erk, p38, and Akt in activated CD4 T cells.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2015.01.030