Correlation between clinical findings and eosinophil/neutrophil ratio in patients with nasal polyps

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a frequent disease which can be classified as eosinophilic or neutrophilic based on dominant inflammatory cell type at tissue. The aim of this study was to evaluate the clinical relevance of classifying nasal polyps as eosinophilic or neutrophilic...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2015-04, Vol.272 (4), p.915-921
Main Authors: Tecimer, S. Hancer, Kasapoglu, F., Demir, U. L., Ozmen, O. A., Coskun, H., Basut, O.
Format: Article
Language:English
Subjects:
Adult
Chronic Disease
Endoscopy - methods
Eosinophilia - diagnosis
Eosinophils - pathology
Female
Head and Neck Surgery
Humans
Male
Medicine
Medicine & Public Health
Nasal Polyps - etiology
Nasal Polyps - pathology
Nasal Polyps - surgery
Nasal Polyps - therapy
Neurosurgery
Neutrophils - pathology
Otorhinolaryngology
Paranasal Sinuses - pathology
Paranasal Sinuses - surgery
Retrospective Studies
Rhinitis - complications
Rhinitis - diagnosis
Rhinitis - physiopathology
Rhinitis - surgery
Rhinitis - therapy
Rhinology
Sinusitis - complications
Sinusitis - diagnosis
Sinusitis - physiopathology
Sinusitis - surgery
Sinusitis - therapy
Tomography, X-Ray Computed
Treatment Outcome
Turkey
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Summary:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a frequent disease which can be classified as eosinophilic or neutrophilic based on dominant inflammatory cell type at tissue. The aim of this study was to evaluate the clinical relevance of classifying nasal polyps as eosinophilic or neutrophilic on treatment outcomes. The study was conducted with 40 patients who underwent either surgical or medical treatment with the diagnosis of CRSwNP. The patients were classified into two groups for further assessment up to eosinophil intensity at polyp tissue. All patients were examined by nasal endoscopy and paranasal computed tomography (CT). Before treatment, subjective symptom score, nasal endoscopy score, and CT score were measured. Subsequently, they were reevaluated by similar diagnostic tests after either medical or surgical treatment at sixth month. The preoperative subjective symptom score, endoscopy score, and paranasal CT score were compared between chronic rhinosinusitis (CRS) with eosinophilic nasal polyps (E-NP) (CRSwE-NP) group and CRS with neutrophilic nasal polyps group and there was no difference between the two groups ( p  = 0.369, p  = 0.310 and p  = 0.494 respectively). Although after treatment in both groups symptom score and endoscopy score were significantly improved but not the CT score, we found no difference in between the groups at sixth month. In most of the previous studies, patients with CRSwE-NP were assumed to have poor prognosis and high recurrence rate despite surgical or medical treatment. However, we did not find any association between eosinophilic or neutrophilic nature of nasal polyp tissue and disease severity.
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-014-3174-4