The association of plasma vitamin A and E levels with coronary collateral circulation

Abstract Objective To investigate if plasma levels of vitamin A and E have an association with coronary collateral development. Methods A total of 189 patients who underwent coronary angiography and had total occlusion in at least one major epicardial coronary artery were enrolled in the study. To c...

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Bibliographic Details
Published in:Atherosclerosis 2015-04, Vol.239 (2), p.547-551
Main Authors: Söğüt, Erkan, Kadı, Hasan, Karayakalı, Metin, Mertoğlu, Cuma
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
C-Reactive Protein - analysis
Cardiovascular
Chi-Square Distribution
Collateral Circulation
Coronary Angiography
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - physiopathology
Coronary Circulation
Coronary collateral circulation
Coronary Occlusion - blood
Coronary Occlusion - diagnostic imaging
Coronary Occlusion - physiopathology
Diabetes Mellitus
Female
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Predictive Value of Tests
Risk Factors
Vitamin A
Vitamin A - blood
Vitamin E
Vitamin E - blood
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Summary:Abstract Objective To investigate if plasma levels of vitamin A and E have an association with coronary collateral development. Methods A total of 189 patients who underwent coronary angiography and had total occlusion in at least one major epicardial coronary artery were enrolled in the study. To classify coronary collateral circulation (CCC), the Rentrop scoring system was used. Patients were classified as having poor CCC (Rentrop grades 0–1) or good CCC (Rentrop grades 2–3), and all patients were also screened for hypertension, hypercholesterolemia, diabetes, and smoking history. Results There were no differences in plasma vitamin A and E levels between the two groups (vitamin A: 2.37 ± 0.65 vs. 2.35 ± 0.78, p  = 0.253; vitamin E: 47.1 ± 12.8 vs. 44.6 ± 15.1, p  = 0.082), and plasma vitamin A and E levels were not associated with CCC. Serum high-sensitivity C-reactive protein (hs-CRP) levels were significantly higher in patients with poor CCC (4.68 ± 2.52 vs. 3.89 ± 1.78, p  = 0.001). The higher frequency of diabetes and higher serum hs-CRP levels were found to be an independent predictor for poor CCC (odds ratio = 2.44, p  = 0.006; odds ratio = 1.24, p  = 0.007, respectively). And a higher frequency of total occluded RCA was found to be a positive predictor for good CCC (odds ratio = 2.36, p  = 0.06) in a multivariate logistic regression analysis. Conclusions We found that serum hs-CRP levels, presence of diabetes, and total occlusion of RCA have an effect on coronary collateral development. We found no correlation between plasma vitamin A and E levels and CCC.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2015.02.029