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Morphologic Changes of Cerebral Veins in Hypertensive Rats: Venous Collagenosis Is Associated with Hypertension
Background The aims of this study were to determine whether arterial hypertension could affect the venous system of brain and to find out the consequent pathologic changes of cerebral veins. Methods Thirty male Sprague–Dawley rats were divided into 2 groups: a sham-clipped group and a stroke-prone r...
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| Published in: | Journal of stroke and cerebrovascular diseases 2015-03, Vol.24 (3), p.530-536 |
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| container_end_page | 536 |
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| container_title | Journal of stroke and cerebrovascular diseases |
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| creator | Zhou, Min, MD Mao, Lijuan, MD, MS Wang, Ying, MD, PhD Wang, Qian, MD Yang, Zhiyun, MD, PhD Li, Shurong, MD, MS Li, Ling, MD, PhD |
| description | Background The aims of this study were to determine whether arterial hypertension could affect the venous system of brain and to find out the consequent pathologic changes of cerebral veins. Methods Thirty male Sprague–Dawley rats were divided into 2 groups: a sham-clipped group and a stroke-prone renovascular hypertensive rat group. A 2-kidney 2-clip rat model was used to induce renovascular hypertension in the hypertensive group. Systolic blood pressure was measured by tail cuff once each week. Susceptibility-weighted imaging (SWI) was performed at 12, 16, and 20 weeks after surgery. All the rats were sacrificed after the SWI examination at 20 weeks after surgery. The brains were extracted and embedded in paraffin for histologic examination. Masson trichrome staining was performed to identify venous collagenosis. Results The sham group demonstrated less prominence of cerebral veins compared with hypertensive groups ( P |
| doi_str_mv | 10.1016/j.jstrokecerebrovasdis.2014.09.038 |
| format | article |
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Methods Thirty male Sprague–Dawley rats were divided into 2 groups: a sham-clipped group and a stroke-prone renovascular hypertensive rat group. A 2-kidney 2-clip rat model was used to induce renovascular hypertension in the hypertensive group. Systolic blood pressure was measured by tail cuff once each week. Susceptibility-weighted imaging (SWI) was performed at 12, 16, and 20 weeks after surgery. All the rats were sacrificed after the SWI examination at 20 weeks after surgery. The brains were extracted and embedded in paraffin for histologic examination. Masson trichrome staining was performed to identify venous collagenosis. Results The sham group demonstrated less prominence of cerebral veins compared with hypertensive groups ( P < .01); the hypertensive group showed significant venous collagenosis in cerebral venous walls compared with the sham group ( P < .01). Conclusions The increased visibility of cerebral veins on SWI as a sign of venous hypertension and the thickened cerebral venous walls (venous collagenosis), which may play a role in cerebral ischemia and/or infarction, are both consequences of long-term hypertension in hypertensive rats.</description><identifier>ISSN: 1052-3057</identifier><identifier>EISSN: 1532-8511</identifier><identifier>DOI: 10.1016/j.jstrokecerebrovasdis.2014.09.038</identifier><identifier>PMID: 25534370</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Arterial Pressure ; Biopsy ; Cardiovascular ; Cerebral Veins - metabolism ; Cerebral Veins - pathology ; Cerebral Veins - physiopathology ; cerebral venous change ; Cerebrovascular Disorders - etiology ; Cerebrovascular Disorders - metabolism ; Cerebrovascular Disorders - pathology ; Cerebrovascular Disorders - physiopathology ; Collagen - metabolism ; Collagen Diseases - etiology ; Collagen Diseases - metabolism ; Collagen Diseases - pathology ; Collagen Diseases - physiopathology ; Disease Models, Animal ; hypertension ; Hypertension, Renovascular - complications ; Hypertension, Renovascular - physiopathology ; Magnetic Resonance Imaging ; Male ; Neurology ; Rats, Sprague-Dawley ; Risk Factors ; stroke-prone renovascular hypertensive rat ; Susceptibility-weighted imaging ; Time Factors ; Vascular Remodeling ; venous collagenosis</subject><ispartof>Journal of stroke and cerebrovascular diseases, 2015-03, Vol.24 (3), p.530-536</ispartof><rights>National Stroke Association</rights><rights>2015 National Stroke Association</rights><rights>Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-979528d300b20b9c67cc4a20bd5e58db2d7fcaad1b5f5f9bfc404dbe53a7f17a3</citedby><cites>FETCH-LOGICAL-c529t-979528d300b20b9c67cc4a20bd5e58db2d7fcaad1b5f5f9bfc404dbe53a7f17a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25534370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Min, MD</creatorcontrib><creatorcontrib>Mao, Lijuan, MD, MS</creatorcontrib><creatorcontrib>Wang, Ying, MD, PhD</creatorcontrib><creatorcontrib>Wang, Qian, MD</creatorcontrib><creatorcontrib>Yang, Zhiyun, MD, PhD</creatorcontrib><creatorcontrib>Li, Shurong, MD, MS</creatorcontrib><creatorcontrib>Li, Ling, MD, PhD</creatorcontrib><title>Morphologic Changes of Cerebral Veins in Hypertensive Rats: Venous Collagenosis Is Associated with Hypertension</title><title>Journal of stroke and cerebrovascular diseases</title><addtitle>J Stroke Cerebrovasc Dis</addtitle><description>Background The aims of this study were to determine whether arterial hypertension could affect the venous system of brain and to find out the consequent pathologic changes of cerebral veins. Methods Thirty male Sprague–Dawley rats were divided into 2 groups: a sham-clipped group and a stroke-prone renovascular hypertensive rat group. A 2-kidney 2-clip rat model was used to induce renovascular hypertension in the hypertensive group. Systolic blood pressure was measured by tail cuff once each week. Susceptibility-weighted imaging (SWI) was performed at 12, 16, and 20 weeks after surgery. All the rats were sacrificed after the SWI examination at 20 weeks after surgery. The brains were extracted and embedded in paraffin for histologic examination. Masson trichrome staining was performed to identify venous collagenosis. Results The sham group demonstrated less prominence of cerebral veins compared with hypertensive groups ( P < .01); the hypertensive group showed significant venous collagenosis in cerebral venous walls compared with the sham group ( P < .01). Conclusions The increased visibility of cerebral veins on SWI as a sign of venous hypertension and the thickened cerebral venous walls (venous collagenosis), which may play a role in cerebral ischemia and/or infarction, are both consequences of long-term hypertension in hypertensive rats.</description><subject>Animals</subject><subject>Arterial Pressure</subject><subject>Biopsy</subject><subject>Cardiovascular</subject><subject>Cerebral Veins - metabolism</subject><subject>Cerebral Veins - pathology</subject><subject>Cerebral Veins - physiopathology</subject><subject>cerebral venous change</subject><subject>Cerebrovascular Disorders - etiology</subject><subject>Cerebrovascular Disorders - metabolism</subject><subject>Cerebrovascular Disorders - pathology</subject><subject>Cerebrovascular Disorders - physiopathology</subject><subject>Collagen - metabolism</subject><subject>Collagen Diseases - etiology</subject><subject>Collagen Diseases - metabolism</subject><subject>Collagen Diseases - pathology</subject><subject>Collagen Diseases - physiopathology</subject><subject>Disease Models, Animal</subject><subject>hypertension</subject><subject>Hypertension, Renovascular - complications</subject><subject>Hypertension, Renovascular - physiopathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Neurology</subject><subject>Rats, Sprague-Dawley</subject><subject>Risk Factors</subject><subject>stroke-prone renovascular hypertensive rat</subject><subject>Susceptibility-weighted imaging</subject><subject>Time Factors</subject><subject>Vascular Remodeling</subject><subject>venous collagenosis</subject><issn>1052-3057</issn><issn>1532-8511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqVkt2L1DAUxYso7of-C5JHEVrz0bSND8JaXHdhRPDrNaTJ7UxmO8mY2xmZ_96Ms4qILz7lQE7Ouflxi-IFoxWjrHm5rtY4p3gHFhIMKe4NOo8Vp6yuqKqo6B4U50wKXnaSsYdZU8lLQWV7VlwgrillTHbycXHGpRS1aOl5Ed_HtF3FKS69Jf3KhCUgiSPpf1aYiXwFH5D4QG4OW0gzBPR7IB_NjK_yXYg7JH2cJrPMGj2SWyRXiNF6M4Mj3_28-uNlDE-KR6OZEJ7en5fFl-u3n_ubcvHh3W1_tSit5GouVask75ygdOB0ULZpra1Nlk6C7NzAXTtaYxwb5ChHNYy2prUbQArTjqw14rJ4fsrdpvhtBzjrjUcLedAAeWbNmqZmqqWCZ-ubk9WmiJhg1NvkNyYdNKP6CF6v9b_A6yN4TZXO4HPIs_u-3bAB9zviF-lsWJwMkH-995A0Wg_BgvMJ7Kxd9P_X9_qvODv54K2Z7uAAuI67FDJfzTRyTfWn4yocN4HVlNZKNeIHoVC6eQ</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Zhou, Min, MD</creator><creator>Mao, Lijuan, MD, MS</creator><creator>Wang, Ying, MD, PhD</creator><creator>Wang, Qian, MD</creator><creator>Yang, Zhiyun, MD, PhD</creator><creator>Li, Shurong, MD, MS</creator><creator>Li, Ling, MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>Morphologic Changes of Cerebral Veins in Hypertensive Rats: Venous Collagenosis Is Associated with Hypertension</title><author>Zhou, Min, MD ; Mao, Lijuan, MD, MS ; Wang, Ying, MD, PhD ; Wang, Qian, MD ; Yang, Zhiyun, MD, PhD ; Li, Shurong, MD, MS ; Li, Ling, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-979528d300b20b9c67cc4a20bd5e58db2d7fcaad1b5f5f9bfc404dbe53a7f17a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Arterial Pressure</topic><topic>Biopsy</topic><topic>Cardiovascular</topic><topic>Cerebral Veins - metabolism</topic><topic>Cerebral Veins - pathology</topic><topic>Cerebral Veins - physiopathology</topic><topic>cerebral venous change</topic><topic>Cerebrovascular Disorders - etiology</topic><topic>Cerebrovascular Disorders - metabolism</topic><topic>Cerebrovascular Disorders - pathology</topic><topic>Cerebrovascular Disorders - physiopathology</topic><topic>Collagen - metabolism</topic><topic>Collagen Diseases - etiology</topic><topic>Collagen Diseases - metabolism</topic><topic>Collagen Diseases - pathology</topic><topic>Collagen Diseases - physiopathology</topic><topic>Disease Models, Animal</topic><topic>hypertension</topic><topic>Hypertension, Renovascular - complications</topic><topic>Hypertension, Renovascular - physiopathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Neurology</topic><topic>Rats, Sprague-Dawley</topic><topic>Risk Factors</topic><topic>stroke-prone renovascular hypertensive rat</topic><topic>Susceptibility-weighted imaging</topic><topic>Time Factors</topic><topic>Vascular Remodeling</topic><topic>venous collagenosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Min, MD</creatorcontrib><creatorcontrib>Mao, Lijuan, MD, MS</creatorcontrib><creatorcontrib>Wang, Ying, MD, PhD</creatorcontrib><creatorcontrib>Wang, Qian, MD</creatorcontrib><creatorcontrib>Yang, Zhiyun, MD, PhD</creatorcontrib><creatorcontrib>Li, Shurong, MD, MS</creatorcontrib><creatorcontrib>Li, Ling, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of stroke and cerebrovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Min, MD</au><au>Mao, Lijuan, MD, MS</au><au>Wang, Ying, MD, PhD</au><au>Wang, Qian, MD</au><au>Yang, Zhiyun, MD, PhD</au><au>Li, Shurong, MD, MS</au><au>Li, Ling, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphologic Changes of Cerebral Veins in Hypertensive Rats: Venous Collagenosis Is Associated with Hypertension</atitle><jtitle>Journal of stroke and cerebrovascular diseases</jtitle><addtitle>J Stroke Cerebrovasc Dis</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>24</volume><issue>3</issue><spage>530</spage><epage>536</epage><pages>530-536</pages><issn>1052-3057</issn><eissn>1532-8511</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Background The aims of this study were to determine whether arterial hypertension could affect the venous system of brain and to find out the consequent pathologic changes of cerebral veins. Methods Thirty male Sprague–Dawley rats were divided into 2 groups: a sham-clipped group and a stroke-prone renovascular hypertensive rat group. A 2-kidney 2-clip rat model was used to induce renovascular hypertension in the hypertensive group. Systolic blood pressure was measured by tail cuff once each week. Susceptibility-weighted imaging (SWI) was performed at 12, 16, and 20 weeks after surgery. All the rats were sacrificed after the SWI examination at 20 weeks after surgery. The brains were extracted and embedded in paraffin for histologic examination. Masson trichrome staining was performed to identify venous collagenosis. Results The sham group demonstrated less prominence of cerebral veins compared with hypertensive groups ( P < .01); the hypertensive group showed significant venous collagenosis in cerebral venous walls compared with the sham group ( P < .01). Conclusions The increased visibility of cerebral veins on SWI as a sign of venous hypertension and the thickened cerebral venous walls (venous collagenosis), which may play a role in cerebral ischemia and/or infarction, are both consequences of long-term hypertension in hypertensive rats.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25534370</pmid><doi>10.1016/j.jstrokecerebrovasdis.2014.09.038</doi><tpages>7</tpages></addata></record> |
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| source | ScienceDirect Freedom Collection |
| subjects | Animals Arterial Pressure Biopsy Cardiovascular Cerebral Veins - metabolism Cerebral Veins - pathology Cerebral Veins - physiopathology cerebral venous change Cerebrovascular Disorders - etiology Cerebrovascular Disorders - metabolism Cerebrovascular Disorders - pathology Cerebrovascular Disorders - physiopathology Collagen - metabolism Collagen Diseases - etiology Collagen Diseases - metabolism Collagen Diseases - pathology Collagen Diseases - physiopathology Disease Models, Animal hypertension Hypertension, Renovascular - complications Hypertension, Renovascular - physiopathology Magnetic Resonance Imaging Male Neurology Rats, Sprague-Dawley Risk Factors stroke-prone renovascular hypertensive rat Susceptibility-weighted imaging Time Factors Vascular Remodeling venous collagenosis |
| title | Morphologic Changes of Cerebral Veins in Hypertensive Rats: Venous Collagenosis Is Associated with Hypertension |
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