Morphologic Changes of Cerebral Veins in Hypertensive Rats: Venous Collagenosis Is Associated with Hypertension

Background The aims of this study were to determine whether arterial hypertension could affect the venous system of brain and to find out the consequent pathologic changes of cerebral veins. Methods Thirty male Sprague–Dawley rats were divided into 2 groups: a sham-clipped group and a stroke-prone r...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2015-03, Vol.24 (3), p.530-536
Main Authors: Zhou, Min, MD, Mao, Lijuan, MD, MS, Wang, Ying, MD, PhD, Wang, Qian, MD, Yang, Zhiyun, MD, PhD, Li, Shurong, MD, MS, Li, Ling, MD, PhD
Format: Article
Language:English
Subjects:
Animals
Arterial Pressure
Biopsy
Cardiovascular
Cerebral Veins - metabolism
Cerebral Veins - pathology
Cerebral Veins - physiopathology
cerebral venous change
Cerebrovascular Disorders - etiology
Cerebrovascular Disorders - metabolism
Cerebrovascular Disorders - pathology
Cerebrovascular Disorders - physiopathology
Collagen - metabolism
Collagen Diseases - etiology
Collagen Diseases - metabolism
Collagen Diseases - pathology
Collagen Diseases - physiopathology
Disease Models, Animal
hypertension
Hypertension, Renovascular - complications
Hypertension, Renovascular - physiopathology
Magnetic Resonance Imaging
Male
Neurology
Rats, Sprague-Dawley
Risk Factors
stroke-prone renovascular hypertensive rat
Susceptibility-weighted imaging
Time Factors
Vascular Remodeling
venous collagenosis
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Summary:Background The aims of this study were to determine whether arterial hypertension could affect the venous system of brain and to find out the consequent pathologic changes of cerebral veins. Methods Thirty male Sprague–Dawley rats were divided into 2 groups: a sham-clipped group and a stroke-prone renovascular hypertensive rat group. A 2-kidney 2-clip rat model was used to induce renovascular hypertension in the hypertensive group. Systolic blood pressure was measured by tail cuff once each week. Susceptibility-weighted imaging (SWI) was performed at 12, 16, and 20 weeks after surgery. All the rats were sacrificed after the SWI examination at 20 weeks after surgery. The brains were extracted and embedded in paraffin for histologic examination. Masson trichrome staining was performed to identify venous collagenosis. Results The sham group demonstrated less prominence of cerebral veins compared with hypertensive groups ( P  
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2014.09.038